20-21 November 2014
National Centre for Synchrotron Science
Australia/Melbourne timezone
Save the date: User Meeting 2015 - 26-27 November
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Displaying 147 contributions out of 147
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 603
Nanodiamonds with nitrogen vacancy (N-V) centres have been shown to be useful for applications involving cellular tracking in vivo at the molecular level[1]. The sustained fluorescence of these nanodiamonds is related to their structure, and is supposed to be influenced by the strain distribution inside the crystals. In the present work, Bragg coherent diffractive imaging (BCDI) has been employed ... More
Presented by Mr. Muhammad Salman MAQBOOL on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials II
Track: Advanced Materials
Solvothermal syntheses are very versatile for fabricating nanostructured materials. While the majority of studies focus on materials syntheses, little attention has been paid to understanding the synthesis mechanisms, which are of vital importance to the rational design of synthesis for preparing optimized materials. In this context, <i>in situ</i> powder X-ray diffraction (PXRD) is ideal to study ... More
Presented by Dr. Fang XIA on 21 Nov 2014 at 14:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Radiotherapy and Radiobiology Board #: 801
Spectroscopy has the potential to be a powerful tool for the quality assurance (QA) of radiotherapy beams; however, direct measurement using spectroscopy detectors is confounded by pulse pile up effects. This is particularly significant for high dose rate, synchrotron based stereotactic radiotherapy modalities such as microbeam radiation therapy (MRT). We herein investigate a Compton spectroscopy ... More
Presented by Dr. Iwan CORNELIUS on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 201
Reliable, robust, and predictable control of motion axes is a key component to any synchrotron beamline. To this end, new motion controls hardware (Geo-Brick-LV-GBLV, Delta-Tau-UK) was recently introduced at the XAS, IMBL, SXR and XFM Beamlines. Challenges included optimising and tuning motion axes behaviour for in-vacuum motors, closed-loop tracking axes, and scanners with velocity requirements. ... More
Presented by Mr. Nader AFSHAR on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 105
The synthesis, structure, bonding and reactivity of molecular compounds containing unusual metal-metal bonds continues to be a topic of considerable interest. We have added to this field by utilising extremely bulky monodentate amido ligands for the stabilisation of a number of low oxidation state transition metal complexes, of which some have shown reactivity comparable to that of the classical G ... More
Presented by Mr. Jamie HICKS on 20 Nov 2014 at 17:30
Type: Oral Session: Structural Biology II
Track: Structural Biology
Malaria is caused by parasites of the genus Plasmodium, with Plasmodium falciparum (Pf) causing the most deaths. The prevention and treatment of Pf malaria is becoming increasingly difficult due to the spread of drug resistant parasites. New therapeutics with a novel mode of action are desperately required. Two Plasmodium falciparum aminopeptidases, PfA-M1 and PfA-M17, play crucial roles in the er ... More
Presented by Dr. Nyssa DRINKWATER on 21 Nov 2014 at 11:45
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 304
In the body, triglyceride oils are digested into amphiphilic fatty acid and monoglyceride. These products subsequently self-assemble into a range of structures, including liquid crystal phases.1,2 It is hoped that understanding their digestion and self-assembly processes offers new opportunities for lipophilic drug delivery. Previous studies using small angle scattering and cryo-TEM have identifie ... More
Presented by Dr. Adrian HAWLEY on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 403
One of the biggest challenges of the 21st century is to develop methods of producing cheap, carbon-neutral, clean energy.(1) The Sun is a forefront renewable energy source, however current solar technologies are limited by the Sun’s diurnal nature. To become a viable future technology, solar energy systems will need to efficiently convert sunlight into energy, and then provide a method of storin ... More
Presented by Ms. Hannah KING on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 114
Materials that exhibit significant mobility of different types of charge carriers have potential applications as fuel-cell membranes, electrodes, batteries and sensors. A thorough understanding of the fundamental atomic-scale mechanisms of the conduction processes in these materials is necessary to identify ways in which their local chemistry and structure can be modified to lower activation barri ... More
Presented by Ms. Julia WIND on 20 Nov 2014 at 17:30
Type: Oral Session: Radiotherapy and Radiobiology
Track: Radiotherapy and Radiobiology
Due to the very high dose rates (kGy/s) used in microbeam radiotherapy (MRT), rigorous fluence monitoring is necessary both for pre-treatment verification, and during therapy. We propose an in-beam monitoring system comprised of a 50 μm film of polyethylene terephthalate (PET) metalised with Aluminium positioned in the beam, coupled with a CMOS imaging system for the collection of fluorescence op ... More
Presented by Dr. Christopher POOLE on 21 Nov 2014 at 13:45
Type: Oral Session: Beamlines, Instrumentation and Techniques I
Track: Beamlines, Instrumentation and Techniques
In 2012-13, the Australian Synchrotron installed a superconducting multi-pole wiggler (SCMPW) on the imaging and medical beamline (IMBL) with the intention of future preclinical radiotherapy trials. Before moving to such trials, accurate knowledge of the dose delivered is required to calibrate the secondary dosimeters in regular use. When this is resolved, clinical use of the Australian Synchrot ... More
Presented by Dr. Peter HARTY on 20 Nov 2014 at 15:50
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Surface Science Board #: 1101
Topological insulators, such as Bi2Se3, are a new class of material that possess topologically protected Dirac surface states that hold great promise for next generation nano-electronic devices [1]. However, major challenges exist in realizing Bi2Se3 devices that operate in the topological regime in air. The first is that as-prepared Bi2Se3 is invariably n-type doped due to selenium vacancies [1], ... More
Presented by Dr. Mark EDMONDS on 20 Nov 2014 at 17:30
Type: Oral Session: Working with Industry
Memjet is a privately held technology company that develops printheads and associated technology for high-speed, low cost digital colour printing. The Memjet Waterfall Printhead Technology comprises a page width printhead made up of 70,400 nozzles, which can continuously fire up to 700 million drops per second. A typical A4 page can be printed in one pass, without scanning back and forth, in 1.6 ... More
Presented by Dr. Derek PERT on 20 Nov 2014 at 11:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 402
The powder diffraction beamline at the Australian Synchrotron exploits the unique properties of synchrotron radiation by offering tunable wavelengths (6 keV – 30 keV) to minimise sample absorption, high flux and good S/N for increased detection limits, and high resolution to minimise peak overlap. The X-ray powder diffraction beamline produces bright, high collimated X-ray beams that, when combi ... More
Presented by Dr. Helen BRAND on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 212
The User Portal facilitates all aspects of user engagement with the synchrotron from proposal submission, down to processing data on massive and inputting subsequent publications. Ongoing development aims to enhance user experience, improve access to data and increase reporting output; for the users, the Australian Synchrotron and funding bodies.
Presented by Lauren BAIRD, Andreas MOLL, Rosemary WAGHORN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1004
The 140 residue intrinsically disordered protein -synuclein (-syn) misfolds to form fibrils that are the major constituent of the Lewy body intracellular protein inclusions and neurotoxic oligomers occurring in a number of neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies. Using SAXS data analysed by ensemble optimised modelling (EOM) we have been able ... More
Presented by Dr. Cyril CURTAIN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1002
Methoxyphenols (MPs) are antioxidants play an important role in degenerative diseases & cancers. Methoxyphenols are found in many food products however, the molecular details of methoxyphenols are limitedly known. o-methoxyphenol (oMP), m-methoxyphenol (mMP) and p-methoxyphenol (pMP) are positional isomers of one another. The electronic structures, properties and spectra of oMP, mMP & pMP were stu ... More
Presented by Prof. Feng WANG, Ms. Rebecca AUCHETTL on 20 Nov 2014 at 17:30
Type: Oral Session: Beamlines, Instrumentation and Techniques II
Track: Beamlines, Instrumentation and Techniques
Bragg Coherent Diffractive Imaging (BCDI) is a technique which is rapidly gaining in popularity throughout the X-ray microscopy community. BCDI allows the characterisation of both the shape and three-dimensional deformation field of nanocrystals at spatial resolutions approaching a few nm. Typically BCDI is sensitive to displacements of < 10-4 of a lattice spacing (Abbey, JOM, 2013). Measurement ... More
Presented by Mr. Nicholas PHILLIPS on 20 Nov 2014 at 16:10
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 203
Calorimetry is the most accurate method of quantifying the x-ray flux and dose in the synchrotron beam lines for medical and research applications. In calorimetry, the radiation dose absorbed results in raising the temperature of the absorbing medium which is measured accurately. Several absorbing media have been tried but graphite with relatively low specific heat and zero heat defect has been t ... More
Presented by Dr. Ganesan RAMANATHAN on 20 Nov 2014 at 17:30
Type: Oral Session: Earth and Environment
Track: Earth and Environment
Carbon storage in soil is essential for soil productivity while being directly linked to climate change. Mapping microaggregate-associated forms of soil organic carbon can help understanding the mechanisms of carbon stabilization in soil, revealing molecular organization, physical protection in soil particles and co-localization of carbon sources with microbial processes. Spatially-resolved anal ... More
Presented by Dr. MARIA C. HERNANDEZ-SORIANO on 21 Nov 2014 at 14:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Soft Matter Board #: 903
Leather is a complex biomaterial largely composed of collagen fibrils. As skins are processed to produce leather, chemical and physical changes take place that affect the physical properties of the material. The structural foundation of these changes at the collagen fibril level is not fully understood and formed the basis of this investigation. Synchrotron-based small-angle X-ray scattering was u ... More
Presented by Ms. Katie H. SIZELAND on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1012
The biological functions of proteins depend on the ability of the proteins to fold correctly. Misfolding/unfolding of proteins can cause formation of insoluble pathological aggregates, leading to degenerative diseases, such as Alzheimer’s and Parkinson’s [1]. Although considerable studies have been carried out on the molecular mechanism of protein aggregation, the lack of detailed information ... More
Presented by Gloria XUN on 20 Nov 2014 at 17:30
Type: Oral Session: Surface Science
Track: Surface Science
Vast quantities of bauxite ore, used for the production of alumina (Al2O3) via the Bayer process, contain appreciable concentrations of reactive silicates. Secondary precipitation of these silicates within Bayer plants results in deleterious scale formation consisting largely of aluminosilicate and titanate phases, with resulting losses of caustic soda and decreased heat transfer efficiency. In sp ... More
Presented by Ms. Lina SHI on 20 Nov 2014 at 14:40
Type: Oral Session: Beamlines, Instrumentation and Techniques I
Track: Beamlines, Instrumentation and Techniques
Microbeam radiation therapy (MRT) at IMBL is based on arrays of 50&mu m wide x-ray beams with a pitch of 400&mu m. The peak-to-valley dose ratio (PVDR) is the ratio of the peak dose to the dose between the microbeams and is an important radiobiological quantity. Accurate measurements of the PVDR require a dosimeter with high spatial resolution, dose rate independence and water equivalence for the ... More
Presented by Dr. Jayde LIVINGSTONE on 20 Nov 2014 at 16:10
Type: Oral Session: Advanced Materials I - Sponsored by AXAA
Track: Advanced Materials
Steels are used extensively in the manufacture of automobiles. They may not sound like advanced materials to those not involved in their development – after all they have been available for centuries. However, if we consider a typical modern automobile, none of the steels found in the structure existed 10 years ago. These are engineering alloys that are being intensively developed and improved, ... More
Presented by Prof. Christopher HUTCHINSON on 20 Nov 2014 at 11:00
Type: Oral Session: Beamlines, Instrumentation and Techniques II
Track: Beamlines, Instrumentation and Techniques
The Macromolecular Crystallography (MX) Beamlines at the Australian Synchrotron collect data on protein samples (PX) and chemical samples (CX). This broad range of sample types requires us to consider a number of experimental and data processing considerations. Protein samples have very large unit cells but diffract weakly, the chemical samples on the other hand have comparatively a very small uni ... More
Presented by Dr. Jason PRICE on 20 Nov 2014 at 15:50
Type: Oral Session: Earth and Environment
Track: Earth and Environment
X-ray fluorescence microscopy (XFM) can be used for elemental and chemical microanalysis across many length scales and is a powerful tool for quantitatively mapping trace elements within whole biological specimens [1]. Advances in X-ray fluorescence detection schemes [2, 3] now enable acquisition at mega-pixel per hour rates which in turn allows collection of 3D information in realistic times. C ... More
Presented by Dr. David PATERSON on 21 Nov 2014 at 14:35
Type: Oral Session: Closing Session
on 21 Nov 2014 at 17:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Radiotherapy and Radiobiology Board #: 803
Results of quantitative evaluation and comparison of dose deposition patterns and radiobiological effects in synchrotron microbeam radiotherapy (MRT) - in particular, the inter-microbeam "valley" dose - for six beam geometries and three different in-beam dose values are presented. The X-Tream dosimeter and Gafchromic film have been used to quantitatively compare the dose distribution resulting fro ... More
Presented by Prof. Michael LERCH on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials I - Sponsored by AXAA
Track: Advanced Materials
Metallic glasses have attracted substantial attention in recent years due to their favourable combinations of high strength and corrosion resistance relative to conventional crystalline alloys. These properties make glassy metals appealing for applications such as surgical tools, electronics and sporting goods. However, glassy metals are metastable and crystallisation occurs when they are subjecte ... More
Presented by Dr. Mark STYLES on 20 Nov 2014 at 12:10
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 113
When high energetic heavy ions penetrate a solid, energy is lost predominantly through inelastic collisions with the target electrons. Such interactions can leave narrow cylindrical trails of damage as the ions traverse through the material, termed ‘ion tracks’. In minerals such as apatite, track formation can occur as a result of spontaneous fission from naturally occurring uranium inclusions ... More
Presented by Saliha MURADOGLU on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 211
The Scientific Computing and IT group at the Australian Synchrotron develops software tools to support beamline science, maximise the user experience and accelerate the scientific outcomes of their beam time. Our suite of open source tools facilitate better and more streamlined data collection integrated with automatic and real-time processing, the results of which can inform decisions about furth ... More
Presented by Lenneke JONG on 20 Nov 2014 at 17:30
Type: Oral Session: Working with Industry
The Australian Synchrotron is continually growing its Industrial customer base. The Synchrotron’s Industry Group has been providing expert support and facilitation between these Industrial clients and collaborators from more traditional academic and research institutes. These collaborations exist across a diverse and expanding range of fields. This presentation will showcase some of the successf ... More
Presented by Dr. Kathryn SPIERS on 20 Nov 2014 at 11:00
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 103
The microstructure and device physics of photovoltaic polymer blends based on the donor polymer BFS4 (a dithienyl-benzo[1,2- b:4,5-b]dithiophene / 5-fluoro-2,1,3-benzothiadiazole co-polymer) paired with the naphthalene diimide-based acceptor polymer P(NDI2OD-T2) will be presented. Efficiencies of over 4% are demonstrated, with an open circuit voltage of greater than 0.9 V achieved. Near-edge x-ray ... More
Presented by Mr. Kedar DESHMUKH on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 602
X-ray coherent diffractive imaging provides high resolution, high sensitivity images of intact cellular specimens without the need for sectioning, staining, or tagging. Recent advances in this field allow high resolution imaged to be obtained with a fraction of the dose than otherwise possible while increasing image quality. Further advances have pushed the technique into the X-ray water-window, o ... More
Presented by Dr. Michael JONES on 20 Nov 2014 at 17:30
Type: Oral Session: Biological Systems
Track: Biological Systems
Synchrotron Fourier transform infrared (SFTIR) spectroscopy provides the best available signal-to-noise which allows for fast, sensitive detection of the holistic biochemistry of single live cells. Recently developed super-resolution fluorescence microscopy (SRFM) techniques based on single molecule emissions can yield an order of magnitude improvement in spatial resolution in the imaging of speci ... More
Presented by Ms. Donna WHELAN on 20 Nov 2014 at 14:00
Type: Oral Session: Structural Biology II
Track: Structural Biology
Dementia is the single greatest cause of disability in older Australians afflicting almost one in ten over the age of 65. In the absence of curative therapies, current treatments aimed at enhancing working memory target the cholinergic system and demonstrate limited efficacy, underpinning the need for a new class of cognitive enhancing drug. Insulin-regulated aminopeptidase (IRAP) is a membrane-bo ... More
Presented by Dr. Stefan HERMANS on 21 Nov 2014 at 12:25
Type: Oral Session: Beamlines, Instrumentation and Techniques II
Track: Beamlines, Instrumentation and Techniques
The Macromolecular Crystallography (MX) beamlines serve the scientific community by enabling research that could not be done elsewhere in Australia. In order to achieve this, we are in a state of continual improvement. Here we present an overview of recently completed, currently being rolled-out, and near future developments at MX1 and MX2. Projects that have been recently completed include a majo ... More
Presented by Dr. Daniel ERIKSSON on 20 Nov 2014 at 15:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 301
The binding affinity of a series of square planar achiral platinum(II) compounds of the type [Pt(AL)(IL)]2+, where AL is 1,2-diaminoethane and IL are 1,10-phenanthroline (phen), 4-methyl-1,10-phenanthroline (4-Mephen), 5-methyl-1,10-phenanthroline (5-Mephen), 4,7-dimethyl-1,10-phenanthroline (47-Me2phen), 5,6-dimethyl-1,10-phenanthroline (56-Me2phen) or 3,4,7,8-tetramethyl-1,10-phenanthroline (347 ... More
Presented by Prof. Janice ALDRICH-WRIGHT on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1001
Ptychography is a method for quantitatively determining the phase of of a samples’ complex transmission function. The technique relies upon the collection of multiple overlapping coherent diffraction patterns from laterally displaced points on the sample. The overlap of measurement points provides complementary information that significantly aids in the reconstruction of the complex wavefield ex ... More
Presented by Mr. Nicholas ANTHONY on 20 Nov 2014 at 17:30
In bulk heterojunction (BHJ) organic photovoltaics (OPVs), electron donating and electron accepting materials form a complex network of discrete and distributed heterointerfaces and charge transport pathways in the photoactive layer where critical photo-physical processes occur. However, little is known about the structural properties of these interfaces due to their 3-dimensional arrangement and ... More
Presented by Prof. Harald ADE on 20 Nov 2014 at 10:00
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1003
Bragg Coherent Diffractive Imaging (BCDI) of radiation hard crystals (e.g. lead, gold) is now a relatively mature technique for characterising elastic strain fields at the nanoscale. The technique relies upon the fact that coherent diffraction from a crystal produces a continuous intensity distribution around every Bragg peak; if sampled correctly, this information can be used to reconstruct the ... More
Presented by Ms. Hannah COUGHLAN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 601
Ptychography has rapidly developed into a widespread technique for high-resolution X-ray microscopy due to improvements in image quality and the added flexibility over conventional Coherent Diffractive Imaging (CDI) techniques. These benefits are achieved via scanning the sample across a finite incident beam such that overlapping regions reinforce the solution for the sample transmission function ... More
Presented by Mr. Guido CADENAZZI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 206
Many of the more demanding surface science experiments at the soft x-ray beamline are often concerned with the interaction between ordered substrates of novel materials and adlayer molecules or thin films. Whilst soft x-ray spectroscopy is extremely powerful in characterizing the chemical information at such interfaces, being able to measure concomitant changes in other physical properties can pro ... More
Presented by Dr. Anton TADICH on 20 Nov 2014 at 17:30
on 20 Nov 2014 at 12:10
Type: Oral Session: Earth and Environment
Track: Earth and Environment
Aluminium (Al) is toxic to plant root growth in the acid soils comprising ca. 40-70% of the world’s arable land, but the mechanisms whereby Al reduces growth remain unclear. Despite 30 µM Al decreasing root growth within 30 min, we are unaware of any study that has provided information on the distribution of Al in roots within this timeframe. Using roots of soybean (Glycine max (L.) Merr.) expo ... More
Presented by Dr. Peter KOPITTKE on 21 Nov 2014 at 13:45
Type: Oral Session: Imaging - Sponsored by MASSIVE
Track: Imaging
Dual energy X-ray analysis (DEXA) uses CT measurements of the X-ray linear attenuation coefficient at two photon energies to characterise materials; electron density and statistical measure of elemental composition, related to the concept of effective atomic number. Phantoms were prepared as liquid samples of known density and composition including ethanol-water mixtures and salt solutions (Na ... More
Presented by Dr. Stewart MIDGLEY on 21 Nov 2014 at 12:05
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 111
Chiral coordination polymers, using ligands that contain large aromatic cores have been used to synthesize a series of polycatenanes and a polyrotaxane, by virtue of π interactions involving metallomacrocyclic motifs, including interpenetrated networks that have been used as stationary phases to obtain excellent enantiomeric resolution in liquid-chromatographic separations. A series of dicarboxy ... More
Presented by Dr. David TURNER on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 607
Coherent diffractive imaging (CDI) is a powerful method for recovering the transmission function of an object from its far-field diffraction pattern using iterative algorithms [1]. Recently, it has been shown that CDI works with partially coherent beam [2]. Methods have been developed for dealing with CDI data for which the coherence properties of the illumination are unkown [3]. In this work, we ... More
Presented by Mr. Giang TRAN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 210
X-ray Absorption Spectroscopy is a technique for structure determination and speciation studies which is well suited to the in situ study extreme environments. Extreme environments are systems under high pressure and high temperature. These systems occur in nature when geofluids dissolve metals from large regions of host rock, and later precipitate the metals as ore deposits. Apart from und ... More
Presented by Mr. Nicholas RAE on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Soft Matter Board #: 902
Self-assembly of molecules on highly oriented pyrolytic graphite (HOPG) to form ordered patterns have been an area of active research since it is relevant to colloidal stabilization, patterning and thin film devices. Most of the works have focused on 2D crystalline layers of the molecules absorbed onto graphite surfaces. However, more and more research has provided the significance of forming 3D-s ... More
Presented by Ms. Song Ha NGUYEN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 303
The promise of non-destructive 3D elemental imaging using x-ray fluorescence tomography is alluring, but the technique is not widely utilised due to the extremely long scan times required for modest tasks. Accordingly, the technique is often applied to imaging of small specimens at low definition. Our first 3D demonstration on a 10-&mu;m estuarine diatom, Cyclotella meneghiniana achieved a resol ... More
Presented by Dr. Martin DE JONGE on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Energy Materials Board #: 503
The structural properties of Ge NPs synthesised by ion implantation in amorphous Si3N4 at 400 oC. A combination of conventional techniques (XRD and RBS) and synchrotron-based method have been used to investigate the properties of NPs. XRD spectra reveals poly crystallization of the matrix for samples annealed at 1100 oC and a peak related to SiGe structure. RBS study indicates diffusion of Ge atom ... More
Presented by Ms. sahar MIRZAEI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 109
The photoluminescence signal of Amorphous silicon oxynitrides can be tunable by controlling their stoichiometry. The change in PL is related to defect centres and phase structures changes <small>[1]</small>. A coupling between the surface plasmon resonace of Au nanoparticles with these PL centres would lead to develop new optoelectronic and light source devices. To study this process we implant ... More
Presented by Mr. Pablo MOTA SANTIAGO on 20 Nov 2014 at 17:30
Type: Oral Session: Earth and Environment
Track: Earth and Environment
The IR spectral region is crucial to our understanding of atmospheric chemistry and physics. Firstly, radiative processes associated with emission and extinction are fundamental to energy transfer and the IR region in particular is central for materials at the moderate temperatures found in non-stellar environments such as this planet’s atmosphere. Secondly, infrared spectroscopy is uniquely sui ... More
Presented by Dr. Evan ROBERTSON on 21 Nov 2014 at 14:55
Type: Oral Session: Imaging - Sponsored by MASSIVE
Track: Imaging
Recent advances in neutron detection technology are enabling collection of neutron transmission data with unprecedented spatial and time resolution [1,2]. Microchannel plates coupled with TimePix area detectors are now being used to perform time-of-flight neutron radiography experiments at 55 micron<sup>2</sup> spatial resolution and 1 &mus temporal resolution. These sensors are suited to a divers ... More
Presented by Mr. Henry KIRKWOOD on 21 Nov 2014 at 12:25
Type: Oral Session: Radiotherapy and Radiobiology
Track: Radiotherapy and Radiobiology
High resolution 3D imaging of microbeam radiation therapy (MRT) microbeams produced on the Australian Synchrotron's IMBL has been achieved using laser fluorescent confocal microscopy (LFCM). Radiosensitive dosimeters have been specifically fabricated to suit the extremely high dose of the MRT microbeams and the geometrical needs of the LFCM. Cross-fire, stereotactic and interlaced MRT beams are ea ... More
Presented by Mr. Frank GAGLIARDI on 21 Nov 2014 at 14:35
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 202
The use of radiochromic film for clinical dosimetry is well established, and in principle these films can provide the high spatial resolution dosimetry required for the microbeam x-ray radiotherapy research taking place on IMBL. The spatial resolution of a measurement made with the radiochromic film is typically limited by the densitometry. For broad beam illuminations (> 1 mm) the spatial resolut ... More
Presented by Dr. Christopher HALL on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 609
A Tudor portrait of Henry VIII on oak dating from 1540s is currently undergoing conservation treatment. This treatment includes the removal of restoration paint layers applied prior to its acquisition by the Art Gallery of New South Wales. Conventional imaging techniques, x-radiography, infrared reflectography and ultraviolet fluorescence suggested damages underneath the restorations. These includ ... More
Presented by Daryl HOWARD on 20 Nov 2014 at 17:30
Type: Oral Session: Soft Matter
Track: Soft Matter
Self-assembled lipidic cubic phases are attracting increasing interest as biocompatible carriers of large biomolecules including proteins, peptides, DNA and drugs [1]. A suite of new high-throughput techniques, to formulate libraries of lipidic mesophases, and structurally characterize them using the SAXS/WAXS beamline at the Australian Synchrotron, are described. Samples are contained within any ... More
Presented by Dr. Charlotte CONN on 20 Nov 2014 at 14:00
Type: Oral Session: Working with Industry
Hospira is a global leader in the manufacture of generic injectable pharmaceuticals. A case study will be presented showcasing the role of the Australian Synchrotron in a recent Hospira investigation.
Presented by Dr. William ISSA on 20 Nov 2014 at 11:50
Type: Oral Session: Structural Biology I
Track: Structural Biology
Abacavir hypersensitivity syndrome (AHS) is a T-cell mediated drug hypersensitivity triggered by the antiretroviral drug abacavir, used in the treatment of HIV infection. It is one of an increasing number of adverse drug reactions found to be associated with specific Human Leukocyte Antigen (HLA) alleles. Occuring exclusively in individuals possessing HLA-B*57:01, this is one of the strongest asso ... More
Presented by Dr. Julian VIVIAN on 20 Nov 2014 at 11:50
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 107
The hydrogen bonding in mixed sulfur/oxygen acceptor systems can be thoroughly investigated using the O-ethylxanthate (or O-alkyldithiocarbonate) family of anions. A series of O-ethylxanthate salts (guanidinium, methylammonium, dimethylammonium, trimethylammonium, tetramethylammonium, tetraethylammonium, and tetrapropylammonium), were structurally characterised using synchrotron X-ray spectroscop ... More
Presented by Ms. Lauren MACREADIE on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials II
Track: Advanced Materials
The contemporary organometallic chemistry stems from the discovery of ferrocene Fe(C5H5)2, i.e., di-cyclopentadienyle iron (FeCp2 or Fc) half a century ago. Since its discovery, the heated debate whether the eclipsed or the staggered is the most stable structure of Fc continues. The fact that electronic structures and many properties of the Fc conformers are strikingly similar has been a key hurdl ... More
Presented by Prof. Feng WANG on 21 Nov 2014 at 14:55
Type: Oral Session: Radiotherapy and Radiobiology
Track: Radiotherapy and Radiobiology
Synchrotron-generated microbeams radiotherapy (MRT) is a novel preclinical radiotherapy,in which synchrotron-generated X-rays are segmented by a collimator, producing intense microbeams. MRT has been shown to be extremely well tolerated by normal tissues including the central nervous system in animal models when compared to conventional radiotherapy (CRT). The aim of this study was to identify gen ... More
Presented by Dr. Yuqing YANG on 21 Nov 2014 at 14:55
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 606
Projection of quantitative element images from fluorescence data collected on the XFM beamline of the Australian Synchrotron equipped with a Maia detector and real-time processor uses the Dynamic Analysis (DA) method in the GeoPIXE software. It uses matrix transformations to achieve least-squares fitting of pixel spectra in X-ray fluorescence imaging and tomography at up to ~3 x 10^7 events per se ... More
Presented by Dr. Chris RYAN on 20 Nov 2014 at 17:30
A novel in meso crystallization method has facilitated the structural determination of several biologically relevant integral membrane proteins (IMPs). However, the method remains poorly understood as IMPs are difficult to express and handle. Analogous to solution based crystallization, in meso crystallization requires extensive screening of precipitant conditions. Bicontinuous cubic phases are th ... More
Presented by Ms. Leonie VAN 'T HAG on 21 Nov 2014 at 09:10
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 106
Bismuth ferrite, BiFeO<sub>3 </sub> (BF) is a multiferroic ceramic familiar for the existence of both strong ferroelectric and magnetic ordering at room temperature. In addition to the multiferroicity, the remarkably high Curie temperature (T<sub>c </sub>) and spontaneous polarization (P<sub>s </sub>) of BF has made it an attractive candidate to replace lead-based Pb(Zr,Ti)O<sub>3 </sub> for indus ... More
Presented by Mr. Neamul KHANSUR on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials I - Sponsored by AXAA
Track: Advanced Materials
The general explanation of how MSNs grow is that the silica monomers hydrolysed from silica precursor adsorbed onto surfactant micelles and condensed into silica to form particles. However, the detailed growth mechanism of MSNs still remains unknown especially for the MSNs with small particle size. Herein, time-resolved SAXS with a synchrotron source was employed to investigate the growth of MSNs ... More
Presented by Mr. Zhifeng YI on 20 Nov 2014 at 11:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Energy Materials Board #: 501
Manganese dioxide is used in many electrochemical applications including catalysis, batteries and electrochemical capacitors. Thin film manganese dioxide electrodes prepared by electrodeposition have been shown to have extremely high capacitive performance [1]. This is due to manganese dioxide thin films having low resistance and high surface area. However, these properties diminish markedly as fi ... More
Presented by Ms. Madeleine DUPONT on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 406
Water is both an important and interesting molecular system that needs to be well understood because it exists in so many fields of research, and more often than not its presence can be undesired. The ice particles in both our own atmosphere, and the ISM, predominantly exist as either small ice particles or silicate dust grains coated with ice which can act as a reaction medium for producing more ... More
Presented by Dr. Evan ROBERTSON on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 407
Ice plays an important role in the atmosphere of earth and the interstellar medium through interaction with radiation and hosting chemical reactions. Ice aerosols in the troposphere scatter and absorb radiation from sun and thus have substantial influence on the temperature of earth. Understanding ice’s behaviour is believed to be essential for predicting the future of earth. Due to its ... More
Presented by Mr. Mahmut RUZI on 20 Nov 2014 at 17:30
Type: Oral Session: Opening Session
Rotary ATPases are ubiquitous protein complexes that couple the translocation of protons through membranes to the synthesis or hydrolysis of ATP and are thus central to biological energy conversion. Eukaryotic F-type ATP synthases use energy stored in transmembrane proton gradients to synthesise the biological energy carrier ATP from ADP and inorganic phosphate. The evolutionary related V-type ATP ... More
Presented by Dr. Daniela STOCK on 19 Nov 2014 at 09:45
Silver nanoparticles (Ag-NPs) constitute a major group of engineered nanomaterials increasingly found in consumer products. These products exploit the unique properties of Ag-NPs such as their antibacterial effects, special optical properties, and high specific surface area and reactivity. However, there are significant concerns regarding the potential for Ag-NPs to pose equally unique risks upon ... More
Presented by Dr. Ryo SEKINE on 20 Nov 2014 at 09:00
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 108
Amorphous silicon oxynitrides (SiO<sub>x</sub>N<sub>y</sub>) are commonly used as barrier material due to their interesting mechanical and chemical properties. However, their application as gradient-index materials makes them also suitable candidates for the synthesis of nanostructures <small>[1]</small>. Here, we present direct evidence for the formation of ion tracks in 1-micron-thick silicon ... More
Presented by Mr. Pablo MOTA SANTIAGO on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 102
Ion irradiation of crystalline germanium (c-Ge) results in the formation of a porous surface, and sometimes buried porous layer. The controlled fabrication of such porous structures has potential applications in lighting, gas detection and catalytic applications. In the present work, we employ a combination of complimentary characterisation techniques to better understand the crystalline-to-porous ... More
Presented by Mrs. Huda ALKHALDI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Soft Matter Board #: 901
Self-assembly lipids have been used to solve a number of G-protein coupled receptor structures to date and the mechanism behind it still remains a mystery. Here we report on two factors; lipid incubation time and protein concentration and investigate three different lipid systems; monoolein (MO), phytantriol (PT) and phytanoyl ethanomide (PE), which influenced the uptake of the Dopamine 2 long (D2 ... More
Presented by Dr. Connie DARMANIN on 20 Nov 2014 at 17:30
Type: Oral Session: Soft Matter
Track: Soft Matter
Fourier methods may be used to reconstruct the scattering length density profile of the unit cell from neutron and x-ray diffraction measurements thus yielding information about the distribution of chemical component. Deuteration of the sample components can be used for phasing of the Fourier reconstruction or to provide contrast between components in bilayer stacks1. We discuss the application o ... More
Presented by Dr. Chris GARVEY on 20 Nov 2014 at 13:30
Type: Oral Session: Imaging - Sponsored by MASSIVE
Track: Imaging
In recent years Coherent Diffractive Imaging (CDI) has rapidly matured into a powerful tool for high-resolution X-ray phase contrast imaging. However, a fundamental limit exists on the size of object that can be imaged when using conventional CDI due to the need to correctly sample the measured diffraction intensities. Ptychography, a technique initially developed for electron microscopy, can over ... More
Presented by Dr. Bo CHEN on 21 Nov 2014 at 11:15
Type: Oral Session: Advanced Materials I - Sponsored by AXAA
Track: Advanced Materials
With the recent availability of X-ray Free Electron Lasers (XFELs) and the prospect of Diffraction Limited Storage Rings (DLSRs) just around the corner, the number of major new scientific breakthroughs in the area of coherent X-rays science is likely to rise sharply over the next few years. The past twelve months has already seen significant progress in the field including 3D imaging of intra-grai ... More
Presented by Dr. Brian ABBEY on 20 Nov 2014 at 11:50
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Board #: 702
An increasing number of industrial users are looking to the SAXS/WAXS and PD beamlines for their materials characterisation needs. In recent years commercially-relevant projects from a broad range of fields, including primary industry, energy materials and mining, have met with success due to staff expertise and dedication and the high quality of the facilities.
Presented by Dr. Tamsyn ROSS on 20 Nov 2014 at 17:30
Type: Oral Session: Biological Systems
Track: Biological Systems
Phototherapy is a well-established therapeutic strategy in dermatology, particularly for the treatment of psoriasis and cutaneous T-cell lymphoma. Treatment may either rely on the cytotoxic effect of light of a particular wavelength (e.g. UVB and narrowband UVB) or may require the use of a sensitizer (e.g. psoralens with UVA). We have developed iodinated DNA minor groove binding bisbenzimidazoles ... More
Presented by Dr. Karagiannis TOM on 20 Nov 2014 at 13:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 112
N-Heterocyclic Carbenes (NHCs) have many advantages to their phosphine analogues and have been used for a variety of catalytic applications. Bis-NHCs in particular have been used where bidentate phosphine complexes have previously been used including polymerisation and cross coupling reactions. Our group has been interested in palladium bis-NHCs with a wide variety of different <i>N</i>-substituen ... More
Presented by Ms. Tanita WIERENGA on 20 Nov 2014 at 17:30
Type: Oral Session: Energy Materials
Track: Energy Materials
Increasingly there is demand for clean energy sources and suitable batteries to store this energy. Manganese dioxide and lithiated variants are a promising alternative to conventional Li-ion cathodes due to their cost, abundance, safety and electrochemical performance. Cathodes which operate by a single-phase lithium insertion/extraction process can offer some intrinsic advantages over those with ... More
Presented by Mr. Wesley DOSE on 21 Nov 2014 at 12:05
Type: Oral Session: Surface Science
Track: Surface Science
Solution-cast, organic field-effect transistors (OFET) have many advantages, such as rapid, large area fabrication, low production cost and flexible substrates making them ideal for specialized application such as flexible displays and radio frequency identification. The small molecule organic semiconductor (OSC) naphthalene diimide (NDI) provides a versatile framework with which to build upon an ... More
Presented by Mr. Adam WELFORD on 20 Nov 2014 at 14:00
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Surface Science Board #: 1102
Near-edge X-ray absorption fine-structure (NEXAFS) spectroscopy is an important tool for probing the structure of conjugated polymer films used in organic electronic devices. High-performance conjugated polymers are often donor-acceptor co-polymers which feature a repeat unit with multiple functional groups. To facilitate better application of NEXAFS spectroscopy to the study of such materials, im ... More
Presented by Dr. Lars THOMSEN on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 101
Pseudo-Grignard reagents1, 2, ‘‘RLnX’’ (Ln = Eu, Sm and Yb; R = Me, Ph or C6H2Me3-2, 4, 6; X = Br, I), formed by the treatment of organic halides like PhBr or PhI with rare earth metals in Lewis base solvents, can be employed to various organic or inorganic transformations3, 4. We now report the synthesis of new divalent rare earth metal formamidinate complex [Ln(Form)Br(thf)2]2 through t ... More
Presented by Mr. Safaa ALI on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials II
Track: Advanced Materials
We have synthesised large (2.7 nm) spherical metallosupramolecules (‘nanoballs’) with interesting properties [1-3]. Metal ions can be varied with retention of overall structure and crystal packing. The molecular packing creates cavities within the solid state, and the crystals readily absorb solvents such as methanol, acetonitrile or acetone (which also changes the magnetic properties), and ab ... More
Presented by Prof. Stuart BATTEN on 21 Nov 2014 at 13:45
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 208
Currently, lasers are being introduced to the THz/FarIR beamline at the Australian Synchrotron. This will allow some new techniques such as steady state pump probe, photolysis and pyrolysis experiments to be undertaken at the beamline. We currently have a high powered cw CO2 laser and a pulsed YAG laser. At the THz beamline, an Enclosive Flow Cooling (EFC) cell is available for use. The EFC ce ... More
Presented by Dr. Dominique APPADOO on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Board #: 703
The Australian Synchrotron is a powerful scientific tool offering state of the art techniques and is ideally positioned to provide services for the evolution and commercialization of the next generation of high-tech products. The increasing pressure to move products to market quickly has required industry to look for new approaches in their development cycle. To this end, industry is embracing the ... More
Presented by Dr. Kathryn SPIERS on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 209
X-ray absorption spectroscopy (XAS) is a technique that typically challenges the performance of its monochromator. The XAS Beamline at the Australian Synchrotron utilises a commercially delivered liquid Nitrogen cooled double crystal monochromator (DCM). This DCM possesses excellent energy and beam offset stability. Some mechanical and electrical improvements have been made in-house to enhance per ... More
Presented by Dr. Chris GLOVER on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1010
The production of diffraction-quality crystals remains the major bottleneck in X-ray crystallography, as shown by data from the main structural biology consortia. By contrast, in certain systems, crystals grow readily in the complex environment of the cell used to express the protein, be it in the natural context or in a recombinant system for overexpression. Recent interest in these <i>in vivo</i ... More
Presented by Marion BOUDES, DAMIA GARRIGA on 20 Nov 2014 at 17:30
In geochemical systems, the relative stability of a given element in one phase or another is known as its partitioning behaviour, and many models of Earth processes are based on the changes in partitioning with pressure (and/or other intensive variables). Since higher pressures favour smaller volumes, changes in partitioning with pressure can be predicted if the pressure-dependence of the volume o ... More
Presented by Ms. Eleanor MARE on 21 Nov 2014 at 09:30
Type: Oral Session: Surface Science
Track: Surface Science
In making organic electronics a reality, donor-acceptor based semiconducting polymers will play a pivotal role. The molecular packing, orientation and crystallinity of semiconducting polymer thin-films strongly influence the performance of organic electronic devices. Grazing Incidence Wide-Angle X-ray Scattering (GIWAXS) collected at the SAXS/WAXS beamline has been used to probe the molecular pack ... More
Presented by Mr. Masrur Morshed NAHID on 20 Nov 2014 at 14:20
Type: Oral Session: Biological Systems
Track: Biological Systems
Developments to enable infrared microspectroscopy to extend beyond the far field diffraction limit are being undertaken at several accelerator facilities worldwide. These include the CLIO Free Electron Laser (Paris, France), LNLS (Campinas, Brazil), and the ALS infrared beamline (Berkeley, USA). Without such developments, the spatial resolution in the mid-IR is typically 3 to 5 microns. Two alte ... More
Presented by Dr. Mark TOBIN on 20 Nov 2014 at 14:40
Type: Oral Session: Imaging - Sponsored by MASSIVE
Track: Imaging
The Imaging and Medical Beamline (IMBL) of the Australian Synchrotron (AS) is now becoming one of the most advanced instruments of this type in the world. It is designed to provide a wide variety of imaging techniques. Three beamline’s enclosures at various distances provide the end user a good choice of beam characteristics ranging from the hi-flux for lower resolution and size up to huge 48x5c ... More
Presented by Dr. Anton MAKSIMENKO on 21 Nov 2014 at 11:45
Type: Oral Session: Energy Materials
Track: Energy Materials
Spotty diffraction rings are symptomatic of large-grained polycrystalline materials. Analysis of these rings falls into a void between single crystal and powder diffraction methods, and is usually dismissed or discussed only briefly and in a qualitative fashion. Recently, we have developed statistical methods for quantitatively analysing the ‘spottiness’ of diffraction rings, such as those obs ... More
Presented by Dr. Bridget INGHAM on 21 Nov 2014 at 11:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1013
A preliminary structure of the protein Yih1 (Yeast impact homologue 1), a protein of partially characterised function, has been obtained by multi-dimensional NMR methods. The ~300-residue protein has two distinct domains of approximately 120 and 160 residues with an approximately 20-residue linker. However, no NOEs could be found involving contacts between the two domains. Solution-state SAXS data ... More
Presented by Prof. Geoffrey JAMESON on 20 Nov 2014 at 17:30
Type: Oral Session: Soft Matter
Track: Soft Matter
When exposed to swift heavy ion irradiation a wide range of materials show formation of ion tracks as a result of their interaction with the material’s electrons. These tracks are narrow, cylindrical-shaped regions of high defect concentration, only a few nanometres in diameter and up to tens of micrometers in length. Ion-irradiated polymers allow the fabrication of microelectronic devices such ... More
Presented by Mr. Daniel SCHAURIES on 20 Nov 2014 at 14:20
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 307
Small-angle x-ray scattering (SAXS) is sensitive to the size and shape of macromolecules in solution. Whilst there can be some uncertainties involved in modelling macromolecular structure directly from SAXS data, relative changes in structure can be measured with a high degree of confidence. The binding of a small-molecule ligand to a large protein in itself is generally too subtle an event to ... More
Presented by Dr. Nathan COWIESON on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 405
Ion tracks consist of narrow (~10 nm), long (~10-100 μm) cylindrical defect regions that are generated by high-velocity heavy ions when they pass through a variety of solids. Such tracks result naturally from fission of uranium inclusions in minerals such as apatite and zircon and are used for determining the age and thermal history of geological material. This so called ‘fission track dating ... More
Presented by Mrs. Allina NADZRI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 404
Chalcopyrite (CuFeS2) is the most abundant copper-bearing mineral. The dissolution of chalcopyrite in mine waste environments is considered to contribute to the serious environmental issue of acid and metalliferous drainage (AMD) through release of toxic aqueous copper, particularly in the presence of microbes, dissolved O2, aqueous Fe3+ and pyrite, with the latter two being associated with enhanc ... More
Presented by Mr. YUBIAO LI on 20 Nov 2014 at 17:30
Type: Oral Session: Closing Session
Presented by Prof. Andrew PEELE on 21 Nov 2014 at 16:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Board #: 701
We offer services from cloning your gene and small scale expression trials, protein purification and crystallisation trials, through to full structure determination.
Presented by Dr. Alan RIBOLDI-TUNNICLIFFE on 20 Nov 2014 at 17:30
Type: Oral Session: Energy Materials
Track: Energy Materials
Zeolite molecular sieves are one of the most important materials for separation of molecules. We discovered smart porous materials for gas separation – zeolites containing cations that function as molecular trapdoors allow guest-selective, size-inverse separations. For example, a “molecular trapdoor” mechanism in specifically tailored zeolites which produces a counter-intuitive size-inverse ... More
Presented by Dr. Qinfen GU on 21 Nov 2014 at 11:45
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 207
Coherent diffractive imaging is a high-resolution method capable of providing phase, chemical and magnetic sensitivity over a large field-of-view[1]. Because iterative algorithms are substituted for image-forming lenses, the technique is not limited by the difficulty of manufacturing X-ray optics. It has been widely adopted by the international synchrotron community and is quickly becoming a routi ... More
Presented by Dr. Grant VAN RIESSEN on 20 Nov 2014 at 17:30
Type: Oral Session: Beamlines, Instrumentation and Techniques I
Track: Radiotherapy and Radiobiology
The IMBL at the Australian Synchrotron is able to provide high-brightness kilovoltage radiation in the energy range 20 – 200 keV. A PTW 30013 Farmer-type ionisation chamber was scanned through a point-like (sub-millimetre) beam and the ionisation signal from the chamber was recorded as a function of position. In this way an image was constructed from the spatial dosimetric response of the chambe ... More
Presented by Dr. Duncan BUTLER on 20 Nov 2014 at 16:30
Type: Oral Session: Surface Science
Track: Surface Science
The new class of topological materials including Bi2Se3 offer opportunities to develop next generation electron devices that utilize spin generation and detection without ferromagnetism [1]. However, the fate of the Bi2Se3 surface upon exposure to atmosphere remains unclear. In particular whilst the topology of Bi2Se3 guarantees the presence of a metallic surface, the topological properties of the ... More
Presented by Dr. Mark EDMONDS on 20 Nov 2014 at 13:30
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, affecting over thirty million people worldwide. The current treatment of wet AMD requires frequent intravitreal injections which are highly invasive and expensive. Therefore, a less invasive and long-lasting treatment is required. One option for achieving such an outcome is using self-assembled lipid-based liq ... More
Presented by Ms. Joanne DU on 21 Nov 2014 at 09:20
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1008
Merozoite surface protein 2 (MSP2) is an unstructured protein of the Plasmodium falciparum merozoite. The two allelic forms of MSP2, 3D7 and FC27, differ in a central variable region which is flanked by conserved N- and C-terminal regions. Vaccine trials using 3D7-MSP2 have shown evidence of strain specific protection despite the detectable presence of conserved region antibodies. This work focuse ... More
Presented by Mr. Jeffrey SEOW on 20 Nov 2014 at 17:30
Type: Oral Session: Structural Biology I
Track: Structural Biology
Apoptotic stimuli activate and oligomerise the pro-apoptotic proteins Bak and Bax resulting in mitochondrial outer membrane permeabilisation and subsequent cell death. Crystal structures by Czabotar et al. (2013) provided novel insights into BH3-only induced Bax activation and oligomerisation, namely the separation of the core and latch domains, followed by core domain dimerisation. Here we provid ... More
Presented by Mr. Jason BROUWER on 20 Nov 2014 at 11:30
Type: Oral Session: Structural Biology II
Track: Structural Biology
Amyloid precursor protein (APP) is a type-I transmembrane protein with a large ectodomain (sAPP), a single transmembrane domain and a cytoplasmic tail. It is cleaved by beta- and gamma-secretases to generate amyloid-β (Aβ), a neurotoxic peptide implicated in Alzheimer’s disease (AD). APP dimerisation is closely linked to Aβ overproduction. It is also implicated in APP signalling as APP is pro ... More
Presented by Ms. Chen GAO on 21 Nov 2014 at 12:05
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1005
Cholesterol-dependent cytolysins (CDCs) constitute a family of bacterial toxins that form pores in many cell types. CDCs are secreted as water-soluble monomers, bind to cholesterol-rich membranes, oligomerise and insert into cell membranes. The presence of membrane cholesterol is required for the formation of large pores in cell membranes. In order to convert from a soluble monomeric protein into ... More
Presented by Dr. Susanne FEIL on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1007
Retromer is a peripheral membrane protein complex that plays a critical role in a broad range of physiological, developmental and pathological processes including Wnt signalling, toxin transport and amyloid production in Alzheimer’s disease. The mammalian retromer complex consists of a core heterotrimeric cargo recognition sub-complex (VPS26, VPS29 and VPS35) associated with a dimer of proteins ... More
Presented by Dr. Suzanne NORWOOD on 20 Nov 2014 at 17:30
Type: Oral Session: Structural Biology II
Track: Structural Biology
Caveola membrane invaginations are a striking feature of many vertebrate cell types, and are critical for cell signaling, endocytosis and mechanotransduction. Their formation depends on the caveolins and the cavin peripheral membrane proteins (cavin1, cavin2, cavin3 and cavin4), although there is currently no atomic level information addressing the mechanisms that underpin caveola assembly. Here w ... More
Presented by Dr. Brett COLLINS on 21 Nov 2014 at 11:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 104
Ge has been considered as a potential alternative material for silicon in fabricating future advanced CMOS devices due to its high hole mobility and low dopant activation temperature. Here we study the effect of In concentration on the structural and electrical properties of Ge with or without C co-implantation. By using extended x-ray absorption fine structure and x-ray absorption near-edge spect ... More
Presented by Mr. Ruixing FENG on 20 Nov 2014 at 17:30
Type: Oral Session: Structural Biology I
Track: Structural Biology
Plasminogen is a 7-domain protein (with an N-terminal Pan-apple domain, five kringle domains and a C-terminal serine protease domain) that adopts a closed, activation-resistant conformation in the circulatory system. The recruitment of plasminogen to its target sites is dependant on the lysine binding sites of the kringle domains. Binding to lysine residues on cell receptors and fibrin clots simul ... More
Presented by Dr. Ruby LAW on 20 Nov 2014 at 12:10
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1009
The magnesium chelatase enzyme catalyses the ATP dependent insertion of Mg+ in to protoporphyrin IX(PPIX) in the first step of the chlorophyll biosynthesis pathway consists three different protein subunits ChlI ChlD and ChlH. The GUN4 protein is a regulatory subunit of Mg-chelatase that binds the chlorophyll biosynthesis intermediates, PPIX and Mg protoporphyrin(Mg-PPIX), stimulates Mg chelatase a ... More
Presented by Mrs. shabnam TARAHI TABRIZI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1006
Infection by the Hepatitis C virus (HCV) affects in the order of 150 million people world-wide with more than 300,000 dying each year from HCV-induced liver disease. The RNA-dependent RNA-polymerase of HCV, NS5b, is widely accepted as an ideal candidate for therapeutic development due to the lack of an equivalent enzymatic activity in normal human cells and the absolute dependence of viral replica ... More
Presented by Dr. Craig MORTON on 20 Nov 2014 at 17:30
Type: Oral Session: Advanced Materials II
Track: Advanced Materials
The degree of hydration of cement pastes is critical for determining properties such as the durability of concrete. As part of an integrated study on the prediction of chloride ingress in reinforced concrete, synchrotron X-ray powder diffraction was used to estimate the degree of hydration of cement pastes. While for the past 20 years the composition of Portland cement has been determined by Rietv ... More
Presented by Dr. Estela GARCEZ on 21 Nov 2014 at 14:35
Type: Oral Session: Radiotherapy and Radiobiology
Track: Radiotherapy and Radiobiology
Microbeam radiation therapy (MRT) is a novel, preclinical modality, with a unique ability to generate less radiation damage to neighbouring normal tissues, while providing efficient ablation to the tumour mass; compared to the currently used Broad Beam (BB) modality. A comprehensive investigation on the mechanisms and side effects of these modalities have not currently been established. Here we co ... More
Presented by Mrs. Jessica VENTURA on 21 Nov 2014 at 14:15
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Structural Biology Board #: 1011
The lack of antibiotic development coupled with the rapid increase of resistance to antibiotics in bacteria, has led to a situation described as an ‘alarming public health crisis’(1). Multi-drug resistant (MDR) bacteria are becoming a significant problem because some bacterial strains cannot be treated with our current strongest and last resort antibiotics. There is an urgent need to develop a ... More
Presented by Roxanne SMITH on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Energy Materials Board #: 504
A uniform ion distribution of Ge+1 ions were achieved through multiple-energy/fluence implantations of Ge ions into 2μm a-Si3N4, which were grown on Si(100) substrates. Implantations were performed at temperatures of -196, 200 and 400 oC, to investigate the effect of implanting temperature on the phase of the matrix. Multiple techniques were used to characterise the evolution of the structural p ... More
Presented by Ms. sahar MIRZAEI on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 204
The soft X-ray beam line has fully implemented a series of reference materials that can be placed into the X-ray beam at the same time as a sample is recorded with NEXAFS. This allows a direct cross check against a calibrated photon energy for every spectrum. All the measured reference spectra are presented here in time this will be transparently integrated into the user data taking
Presented by Bruce COWIE on 20 Nov 2014 at 17:30
Type: Oral Session: Beamlines, Instrumentation and Techniques II
Track: Beamlines, Instrumentation and Techniques
The THz/Far-IR beamline at the Australian Synchrotron is coupled to a Bruker IFS125 FT spectrometer which is equipped with a variety of optical components and detectors covering the spectral range from 10 to 5000 cm-1. Experiments from a variety of fields such as atmospheric and astrophysical sciences, geology, electrochemistry, nano-materials as well as biology have been successfully conducted at ... More
Presented by Ruth PLATHE on 20 Nov 2014 at 16:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Beamlines, Instrumentation and Techniques Board #: 205
The MX1 and MX2 beamlines at the Australian Synchrotron are sophisticated machines for the collection of single crystal X-ray diffraction data. The two stations serve a diverse community of researchers in the structural sciences, from mineralogy to virology. Here we look 'under the hood' at the technologies that bind the individual beamline components together into a highly automated data collect ... More
Presented by Dr. Stephen HARROP on 20 Nov 2014 at 17:30
Type: Oral Session: Beamline updates and discussion
Track: Beamlines, Instrumentation and Techniques
The X-Ray Fluorescence Microscopy beamline has hosted around 250 user groups since it started user operations in 2008, and sustains high levels of oversubscription. Armed with the world-leading Maia detector, and ongoing collaboration with CSIRO, almost 100,000 scans have been performed, representing an estimated 100 Gpixels of data and a stage transit of around 200 km with a positioning accuracy ... More
Presented by Dr. Martin DE JONGE on 20 Nov 2014 at 15:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Radiotherapy and Radiobiology Board #: 802
The aim of the project is to investigate how normal and malignant cell migration is influenced by conventional radiotherapy doses as well as by experimental treatments such as microbeam radiation therapy (MRT). Radiation-induced tumor cell migration is a recognized phenomenon that can occur when cells are sub-lethally irradiated. Our group previously demonstrated that tumor cells showed extens ... More
Presented by Jeff CROSBIE on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Earth and Environment Board #: 401
Jarosites and related minerals are of great interest to a range of mineral processing and research applications. In some settings jarosite formation is encouraged, In other environments jarosite formation can hinder the desired reaction. Jarosites are a major component of acidic soils and are present in significant amounts in acid mine drainage environments. There has been a recent resurgence in i ... More
Presented by Dr. Helen BRAND on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Advanced Materials Board #: 110
Dealloying, used to fabricate nanoporous metals, is a process where less noble components (e.g. Al) in the precursor (e.g. AlCu) are dissolved, leaving the nobler elements (e.g. Cu) to form a nanoporous structure. The three-dimensionally nanoporous Cu is desired in lithium-ion batteries as current collectors, which has a unique advantage in providing large surface area for active materials and can ... More
Presented by Ms. Tingting SONG on 20 Nov 2014 at 17:30
Session: Closing Session
on 21 Nov 2014 at 16:45
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Energy Materials Board #: 502
Organic solar cells are a next generation photovoltaic technology with the potential for a low cost of manufacturing and printing on flexible substrates. The efficiency of organic solar cells has increased rapidly, recently exceeding 9% efficiency. Understanding the morphology of the active layer of polymer based bulk heterojunction solar cells is necessary to further improve device performance. H ... More
Presented by Mr. Wenchao HUANG on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Radiotherapy and Radiobiology Board #: 804
The radiobiology of microbeam radiation therapy (MRT) is poorly understood and this is confounded by difficulties in measuring the dose-distribution. Our investigation assesses the use of microscopy to determine the peak and valley dose in Synchrotron microbeam radiation therapy (MRT). MRT is performed using the horizontal collimator with arrays of 25µm wide x-ray beams with a pitch of 175µm. Th ... More
Presented by Dr. Elizabeth KYRIAKOU on 20 Nov 2014 at 17:30
Type: Oral Session: Energy Materials
Track: Energy Materials
Metal-organic frameworks (MOFs) are crystalline materials that can be synthesised from metal ions or metal-oxide clusters (nodes) and organic building blocks (links).[1] Through careful consideration of the chemistry of the organic links the properties of these materials can be tailored for particular applications. For example, a flexible framework capable of high yielding post-synthetic metallat ... More
Presented by Dr. Chris SUMBY on 21 Nov 2014 at 12:25
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 302
Platinum(II) anticancer drugs, such as cisplatin and carboplatin, bind to DNA coordinately and have many limitations including poor effectiveness against many cancer cell lines, acquired resistance, cross-resistance as well as unwanted side effects. To overcome these limitations we have recently synthesised dinuclear (2,2':6',2''-terpyridine)-based complexes that are connected by thiol chains of v ... More
Presented by Prof. Janice ALDRICH-WRIGHT on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 306
Platinum(II) anticancer complexes incorporating 2,2'-bipyridine (bpy), 4,4'-dimethyl-2,2'-bipyridine (44Me2bpy) and 2-(2'-pyridyl)quinoxaline (2pq) as polyaromatic ligands and cyclic diamines as ancillary ligands have been synthesised and were characterised via several methods including synchrotron radiation X-ray crystallography. The crystal structure of [Pt(44Me2bpy)(1S,2S-diaminocyclohexane)]2+ ... More
Presented by Mr. Benjamin PAGES on 20 Nov 2014 at 17:30
Type: Oral Session: Opening Session
Presented by Prof. Andrew PEELE, Prof. Michael JAMES on 19 Nov 2014 at 09:00
Type: Oral Session: Structural Biology I
Track: Structural Biology
The success or failure of any structure determination effort is dictated by the signal-to-noise ratio, so a quantitative understanding of both signal and noise is needed to have the best chance of success and to avoid wasted effort on samples that simply aren’t good enough. There are three main hurdles to every structure determination effort: the Phase Problem, the Amplitude Problem, and the R- ... More
Presented by Prof. James HOLTON on 20 Nov 2014 at 11:00
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 608
It is now possible to collect very rapid micro-CT scans at IMBL with data collection times down to 16s or less per scan. This makes it possible to collect three-dimensional data on physical systems that are changing over time. While this provides an exciting scientific opportunity it also comes with significant challenges in terms of data storage, reconstruction and analysis. Dealing effectivel ... More
Presented by Sherry MAYO on 20 Nov 2014 at 17:30
Type: Oral Session: Soft Matter
Track: Soft Matter
X-ray (XRR) and Neutron Reflectometry (NR) techniques are vital and widely used for characterising the interfacial structure of thin films normal to a surface. XRR is regularly used to characterise systems such as ion distribution at the ionic-liquid/electrode surface, the structure of thin film organic photovoltaics, the structure of organic light emitting devices, phospholipid membranes at the ... More
Presented by Dr. Stephen HOLT on 20 Nov 2014 at 14:40
Type: Oral Session: Closing Session
The first dedicated beamline for X-ray Absorption Spectroscopy (XAS) was built in 1974, since then XAS has become one of the core competencies of synchrotron radiation facilities and an essential tool for a broad range of scientific disciplines. XAS is a technique that remains closely associated with its roots in bend magnet sources and second generation facilities. In recent years, insertion de ... More
Presented by Dr. Bruce RAVEL on 21 Nov 2014 at 15:45
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 604
Holographic references can enhance the robustness of coherent diffraction imaging experiments and greatly simplify data analysis. However, to date holography has only only been possible with a limited set of special reference waves. We present a new approach to x-ay Fourier-transform holography with an almost unrestricted choice for the reference wave, opening up new avenues to optimize signal-to- ... More
Presented by Dr. Andrew MARTIN on 20 Nov 2014 at 17:30
Type: Oral Session: Beamlines, Instrumentation and Techniques I
Track: Beamlines, Instrumentation and Techniques
The Imaging and Medical Beamline (IMBL) at the Australian Synchrotron has three hutches, centred at 22, 36 and 140m from the source, in which user experiments are performed. Radiotherapy experiments are currently performed in the first of these hutches, and imaging (including tomography) in the second and third hutches. The X-ray source is provided by a superconducting multipole wiggler (SCMPW) i ... More
Presented by Dr. Andrew STEVENSON on 20 Nov 2014 at 15:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Imaging Board #: 605
Micro-X-ray computed tomography is a well established 3D imaging method that plays an important role in fields like materials science, food research, and bio-medical imaging. It is interesting to combine tomography with other techniques, such as X-ray diffraction, for assessing physical properties (density and crystallography) of materials that are heterogeneous on the micrometer scale. The challe ... More
Presented by Dr. Kappen PETER on 20 Nov 2014 at 17:30
Type: Poster Session: Welcome Function, Poster Session, Exhibition
Track: Biological Systems Board #: 305
Radiosensitizers are used in radiotherapy to enhance tumour control of radioresistant hypoxic tumours. Recent studies indicate that the formation of radical anions is a key step. Thus understanding the ionization reactions of radiosensitizers is crucial in evaluating the radiosensitization potential and in developing new and more effective drugs. The present study concentrates on the electronic st ... More
Presented by Ms. Mayanthi GOONEWARDANEA on 20 Nov 2014 at 17:30
Type: Oral Session: Beamline updates and discussion
In this session we will update on the status of the XAS Beamline, including developments of the user science program, status of the 100-element fluorescence detector, status of Hutch-C, recent works completed, and further plans for upgrades and developments. The session will provide ample opportunity for Q &amp; A and for discussing science needs that the XAS Beamline is not catering for, such as ... More
Presented by Dr. Kappen PETER, Dr. Chris GLOVER, Bernt JOHANNESSEN, Mr. Nicholas RAE on 20 Nov 2014 at 16:10
Type: Oral Session: Biological Systems
Track: Biological Systems
A hallmark of neurodegeneration is a failure of homeostatic mechanisms controlling the concentration and distribution of biometals. A major roadblock to understanding the impact of altered biometal homeostasis in neurodegenerative disease is the lack of specific and sensitive techniques capable of providing quantitative subcellular information on biometals in situ. Advances in X-ray fluorescence d ... More
Presented by Prof. Anthony WHITE on 20 Nov 2014 at 14:20