Australian Synchrotron

Session

Session 7 - Biomedicine & Health

19 Nov 2020, 14:50

289. Metal Nanoparticle Radiosensitization for Improving Radiotherapy

Ivan Kempson

19/11/2020, 14:50

Biomedicine and Health

Oral

Ivan Kempson1, Douglass Howard1, Tyron Turnbull1
1 Future Industries Institute, University of South Australia, SA, 5095
Corresponding Author: Ivan.Kempson@unisa.edu.au
Metal nanoparticles have gained market approval for enhancing the effects of ionizing radiation in radiotherapy treatment of cancer. However the mechanism of action of metal nanoparticles exerting their effect remain...

227. Molecular insights into the specificity and potency of metabolite-mediated T-cell immunity

Wael Awad (Monash University)

19/11/2020, 15:20

Biomedicine and Health

Oral

Mucosal associated invariant T (MAIT) cells are an abundant human T cells subset that are variably activated by small-molecule metabolites presented by the MHC class 1 related molecule, MR1. During infection with riboflavin-producing microorganisms, the microbial metabolite 5-amino-6-D-ribitylaminouracil (5-A-RU) reacts with glycolysis byproducts of glyoxal/methylglyoxal forming highly potent...

186. Characterization of SARS-CoV-2 peptides presented by Human Leukocyte Antigen molecules

Dr Christopher Szeto (Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia)

19/11/2020, 15:40

Biomedicine and Health

Oral

To date, the COVID-19 pandemic has claimed 970,000 lives and afflicted more than 31 million individuals. Although a global effort has been enacted for vaccines and drug discovery, our rudimentary understanding of SARS-CoV-2 infection and our own immune defense against this infection remains unclear. Our immune system can naturally overcome viral infection through the presentation of viral...