Australian Synchrotron

Session

Session 14 - Life Science and Structural Biology

20 Nov 2020, 15:05

Zoom Meeting Room

285. Structural studies of G protein-coupled receptors – implications for drug discovery

David Thal (Monash Institute of Pharmaceutical Sciences)

20/11/2020, 15:05

Life Science and Structural Biology

Oral

David Thal1
1 Monash University

Corresponding Author(s): david.thal@monash.edu
G protein-coupled receptors (GPCRs) are key cell-surface proteins that transduce external environmental cues into biochemical signals across the cell membrane. They are the largest superfamily of cell-surface receptors encoded by the human genome and are also the largest class of FDA approved drug targets....

193. An investigation of the T cell response against viruses through a structural lens

Prof. Stephanie Gras (Monash University)

20/11/2020, 15:35

Life Science and Structural Biology

Oral

T cells are a critical part of the immune response, that would determine the fate of an infection and disease outcome. Our Lab is focused on understanding how T cell engage with viral particles, called peptide antigens, that are presented by highly polymorphic molecules called Human Leukocyte Antigens (HLA). T cells have receptors on their surface called T cell receptor (TCR) that allow them...

220. Structural plasticity between homo and heterodimeric IRF4-DNA Interactions

Dr Srinivasan Sundararaj (Australian National University)

20/11/2020, 15:55

Life Science and Structural Biology

Oral

Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) that regulates the gene expression of immune cells including T cells and B cells. Due to its critical role in B and T cell development, IRF4 is linked directly to numerous immune-related disease conditions including B cell-related chronic lymphocytic leukemia (CLL) and adult T cell leukemia (ATL) (1). Structurally, IRF4...

208. Molecular Interplay between SARS-CoV-2 and Human proteins for viral activation and entry, potential drugs and scope of new therapeutics

Naveen Vankadari (Monash University)

20/11/2020, 16:15

Life Science and Structural Biology

Oral

The pandemic Coronavirus Disease 2019 (COVID19) caused by SARS-CoV-2 is a serious public health concern with global mortality reaching 1 million. Whilst the search for a vaccine is underway, there a several antiviral and antibody treatments being clinically evaluated to fill the “therapeutic gap”. The development of potential drugs requires an understanding of SARS-CoV-2 pathogenicity and...

223. Structural characterisation of mitochondrial complex IV assembly factors

Dr Shadi Maghool (School of Chemistry and The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia)

20/11/2020, 16:35

Life Science and Structural Biology

Oral

Cytochrome c oxidase or mitochondrial respiratory chain complex IV catalyses the transfer of electrons from cytochrome c in the intermembrane space, to molecular oxygen in the matrix and therefore contributes to the proton gradient that drives mitochondrial ATP synthesis. Complex IV dysfunction is a significant cause of human mitochondrial disease. Complex IV requires the incorporation of...

234. COVID-19 Research at the MX Beamlines

Dr Eleanor Campbell (ANSTO)

20/11/2020, 16:55

Life Science and Structural Biology

Oral

From March 2020, the Australian Synchrotron joined the rest of Victoria in COVID-19 lockdown, severely limiting the access to beamlines by staff and users. The MX beamlines stayed operational under a COVID-19 Rapid Access scheme, developed to facilitate research into the SARS-Cov-2 virus. A number of user groups pivoted their research interests to include SARS-Cov-2 proteins, and human...