BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//CERN//INDICO//EN
BEGIN:VEVENT
SUMMARY:Structural basis of higher-order assembly formation in Toll-like r
 eceptor 1\,2 and 6 signaling pathway
DTSTART:20211125T073500Z
DTEND:20211125T073600Z
DTSTAMP:20260916T131200Z
UID:indico-contribution-4202@events.synchrotron.org.au
DESCRIPTION:Speakers: Bostjan Kobe\, YAN LI (The University of Queensland)
 \, Jeffrey D Nanson\n\nInnate immunity represents a typical and widely dis
 tributed form of immunity. Innate immune responses are the first line of d
 efense against pathogens\, which can help destroy invaders invertebrate an
 imals\, invertebrates\, and plants. The innate immune system recognizes mi
 croorganisms via pattern-recognition receptors (PRRs). The family of Toll-
 like receptors (TLRs) is a distinct group of PRRs. They detect the microbi
 al components known as pathogen-associated molecular patterns (PAMPs)\, ac
 tivate downstream transcription factors such as nuclear factor-κB (NF-κB
 )\, resulting in a pro-inflammatory response. 10 TLRs have been identified
  in the human TLR family. In humans\, TLR2 can form heterodimers with TLR1
  and TLR6 when binding different types of ligands. The cytoplasmic Toll/in
 terleukin-1 receptor (TIR) domain can be found in all TLRs and is responsi
 ble for transmitting extracellular signals to intracellular cytoplasmic TI
 R domain-containing adaptor proteins through TIR: TIR domain interactions\
 , thus initiating downstream signaling. Two TIR-domain containing adaptor 
 proteins\, Myeloid differentiation primary response 88 (MyD88) and MyD88 a
 daptor-like (MAL) mediate downstream signaling in the TLR2-TLR1/6 signalin
 g pathway. It has been previously demonstrated that higher-order assembly 
 formation occurs in the TLR4 signaling pathway. The mechanism\, which is k
 nown as signaling by cooperative assembly formation (SCAF)\, may occur in 
 all TLR signal transduction. To date\, the transduction mechanisms of TLR2
 -TLR1/6 signaling are still unclear. This research aims to determine the s
 tructural basis of higher-order assemblies formed by TIR domains with a fo
 cus on assemblies in the TLR2-TLR1/6 signaling.\n\nhttps://events.synchrot
 ron.org.au/event/146/contributions/4202/
LOCATION:Online
RELATED-TO:indico-event-146@events.synchrotron.org.au
URL:https://events.synchrotron.org.au/event/146/contributions/4202/
END:VEVENT
END:VCALENDAR