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SUMMARY:Using synchrotron radiation to determine the X-ray structure and c
 t-DNA binding affinity of platinum(II) anticancer complexes
DTSTART:20141120T063000Z
DTEND:20141120T080000Z
DTSTAMP:20260916T130600Z
UID:indico-contribution-718@events.synchrotron.org.au
DESCRIPTION:Speakers: Janice Aldrich-Wright (University of Western Sydney)
 \, Feng Li (University of Western Sydney)\, Yingjie Zhang Zhang (ANSTO)\, 
 Nykola Jones (Department of Physics and Astronomy - Institute for Storage 
 Ring Facilities\, Aarhus University\, Denmark)\, Benjamin Pages (Universit
 y of Western Sydney)\n\nPlatinum(II) anticancer complexes incorporating 2\
 ,2'-bipyridine (bpy)\, 4\,4'-dimethyl-2\,2'-bipyridine (44Me2bpy) and 2-(2
 '-pyridyl)quinoxaline (2pq) as polyaromatic ligands and cyclic diamines as
  ancillary ligands have been synthesised and were characterised via severa
 l methods including synchrotron radiation X-ray crystallography. The cryst
 al structure of [Pt(44Me2bpy)(1S\,2S-diaminocyclohexane)]2+ (44MEBSS) reve
 aled a square planar coordination geometry similar to other complexes of t
 his type  whereas the complex [Pt(2pq)(1S\,2S-diaminocyclohexane)]2+ (2PQS
 S) was distorted square planar.. The binding of 2PQSS and 44MEBSS to calf-
 thymus DNA (ct-DNA) was analysed using synchrotron radiation circular dich
 roism (SRCD) melting experiments and compared to similar complexes that in
 corporate 1\,10-phenanthroline and dipyrido[3\,2-f:2'\,3'-h]quinoxaline. T
 he results revealed unexpected trends in DNA affinity relative to polyarom
 atic ligand size.\n\nhttps://events.synchrotron.org.au/event/3/contributio
 ns/718/
LOCATION:NCSS Exhibition Area
RELATED-TO:indico-event-3@events.synchrotron.org.au
URL:https://events.synchrotron.org.au/event/3/contributions/718/
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