User Meeting 2018

Session

Parallel Session 12

23 Nov 2018, 11:00

Monash Biomedical Imaging Auditorium

Conveners

Parallel Session 12: Structural Biology

• Mark John Hackett (Curtin Univeristy)

33. T cell recognition: few more tricks up their sleeves

Dr Stephanie Gras (Biomedicine Discovery Institute, Monash University. ARC Centre of Excellence in Advanced Molecular Imaging, Monash University. )

23/11/2018, 11:00

Structural Biology

Oral

Our immune system comprises an army of diverse cell types designed to defend our body against infections. These immune cells specifically recognise invaders (pathogens) and, once activated, elicit a targeted attack to eliminate the infection. Within the army of immune cells are cytotoxic T cells equipped with receptors (TCRs). TCRs recognise a fragment of a pathogen (i.e., bits of peptides,...

16. Broad CD8+ T cell receptor cross-recognition of distinct influenza A strains is facilitated by molecular mimicry in humans

Dr Emma Grant (The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Biomedicine Discovery Institute, Monash University )

23/11/2018, 11:30

Structural Biology

Oral

Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of the virus due to minimal antibody-mediated immunity. In that case, established CD8+ T-cells can reduce disease severity. However, as mutations occur sporadically within immunogenic IAV-derived T-cell peptides, understanding of T-cell receptor (TCRab) cross-reactivity towards IAV variants is...

34. Understanding CD4+ TCRs recognition of a single HIV epitope presented by multiple HLA class II molecules

Dr Carine Farenc (Biomedicine Discovery Institute, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia)

23/11/2018, 11:45

Structural Biology

Oral

Human Immunodeficiency Virus (HIV) is a major health issue. With 2 million people newly infected per year, there is an urgent need to develop an HIV cure. Without treatment, HIV infection leads to the progressive disruption of the immune system leading to AIDS, and the occurrence of multiple opportunistic infections.
Surprisingly, a small fraction of HIV-infected individuals (< 0.5%) can...

28. Cholesterol-Dependent Cytolysins: from Water-Soluble State to Membrane Pore

Prof. Michael Parker (Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010, Australia and St. Vincent’s Institute of Medical Research, Victoria 3065, Australia.)

23/11/2018, 12:00

Structural Biology

Oral

Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. The CDCs exhibit a number of unique features amongst pore-forming toxins including an absolute dependence on the presence of cholesterol-rich membranes for their activity and the formation of oligomeric transmembrane pores greater than 150 Å in diameter. The...