ANBUG-AINSE Neutron Scattering Symposium, AANSS 2018

Session

Topical Session 5: Biology

20 Nov 2018, 11:00

AINSE Conference Centre New Illawarra Road Lucas Heights NSW 2234 Australia

Conveners

Topical Session 5: Biology

• Kathleen Wood (Australian Nuclear Science and Technology Organisation)

60. Using neutrons to elucidate the molecular details of enzyme isoform selectivity by small molecule inhibitors.

Zoë Fisher (European Spallation Source ERIC)

20/11/2018, 11:00

Biology

Oral

Human carbonic anhydrase IX (CA IX) expression is activated by hypoxic condition in aggressive, metastatic tumors. Cancer patietns positive for CA IX have generally a poor prognosis. CA IX has emerged as an important cancer target, but efforts to develop isoform selective inhibitors are complicated by the presence of 14 other CA isoforms that share high sequence and structural similarity. This...

26. Understanding the interaction between the Proteus mirabilis Scs proteins using neutron scattering

Andrew Whitten (ANSTO)

20/11/2018, 11:30

Biology

Oral

Correctly forming disulphide bonds is critical to the folding of a wide variety of proteins. Bacterial virulence factors are one class of proteins containing disulfide bonds, thus, an approach to disarm virulent bacterial might involve shutting down the machinery involved in the formation of disulfide bonds. The suppressor of copper sensitivity (Scs) proteins form part of the disulfide bond...

100. Bismuth-NSAIDs as colorectal cancer chemopreventives

Tara Brown (University of Wolloongong)

20/11/2018, 11:50

Biology

Oral

To date, epidemiological studies, animal studies and clinical trials have indicated the potential of non-steroidal anti-inflammatory drugs (NSAIDs) for the chemoprevention of colorectal cancer (CRC) [1]. Unfortunately, the use of NSAIDs for CRC chemoprevention is significantly limited due to the severe gastrointestinal (GI) side effects that have been associated with their long term use [1]....

29. HIERARCHICAL ARCHITECTURE OF CELLULOSE AND ITS INTERACTION WITH OTHER PLANT CELL WALL POLYSACCHARIDES

Prof. Elliot Gilbert (ANSTO)

20/11/2018, 12:10

Biology

Oral

Plant cell walls (PCWs) are extremely complex structures in which cellulose microfibrils are hierarchically assembled and embedded in a multi-component matrix. While the cellulose microfibrils represent the basic building unit providing mechanical strength [1], the matrix components are able to tune the properties of each specific tissue [2-3], increasing the flexibility or limiting the...