Speaker
Mr
Frank Gagliardi
(William Buckland Radiotherapy Centre)
Description
Nanoparticles with high atomic number (Z) have a larger x-ray cross section than biological tissues. Synchrotron beams interact with the nanoparticles to produce Auger electrons which deposit their energy over a short range, typically less than a micron. This characteristic offers the ability to enhance the dose delivered to tumors by synchrotron broad beam (BB) or microbeam radiation therapy (MRT). High Z nanoparticles can also be used as a contrast agent for in-vivo x-ray imaging during the treatment setup.
Here we present our initial findings on the dose enhancement effect for synchrotron beams on the IMBL using UV/Vis spectroscopy with radiosensitive dosimeters irradiated with and without nanoparticles.
| Keywords | Nanoparticles, Dose Enhancement, IMBL |
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Primary author
Mr
Frank Gagliardi
(William Buckland Radiotherapy Centre)
Co-authors
Dr
Andrew Stevenson
(Australian Synchrotron/ CSIRO)
Prof.
Moshi Geso
(RMIT University)
Prof.
Rick Franich
(RMIT University)
