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    User Meeting 2014

    20–21 Nov 2014
    National Centre for Synchrotron Science
    Australia/Melbourne timezone
    Save the date: User Meeting 2015 - 26-27 November

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    Session

    Biological Systems

    20 Nov 2014, 13:30
    National Centre for Synchrotron Science

    National Centre for Synchrotron Science

    Australian Synchrotron 800 Blackburn Road Clayton VIC 3168

    Conveners

    Biological Systems

    • Nathan Cowieson (Australian Synchrotron)

    Presentation materials

    There are no materials yet.

    1. 4. Mechanisms of action of a potent DNA binding UVA photosensitiser using mRNA-sequencing and infrared Synchrotron microspectroscopy
      Dr Karagiannis Tom (Baker IDI Heart and Diabetes Institute)
      20/11/2014, 13:30
      Biological Systems
      Oral
      Phototherapy is a well-established therapeutic strategy in dermatology, particularly for the treatment of psoriasis and cutaneous T-cell lymphoma. Treatment may either rely on the cytotoxic effect of light of a particular wavelength (e.g. UVB and narrowband UVB) or may require the use of a sensitizer (e.g. psoralens with UVA). We have developed iodinated DNA minor groove binding...
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    2. 133. Correlative single cell Fourier transform infrared spectroscopy and super-resolution fluorescence microscopy reveals the effects of fixation on the biochemistry of mammalian cells.
      Ms Donna Whelan (Monash University)
      20/11/2014, 14:00
      Biological Systems
      Oral
      Synchrotron Fourier transform infrared (SFTIR) spectroscopy provides the best available signal-to-noise which allows for fast, sensitive detection of the holistic biochemistry of single live cells. Recently developed super-resolution fluorescence microscopy (SRFM) techniques based on single molecule emissions can yield an order of magnitude improvement in spatial resolution in the imaging of...
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    3. 57. Zinc complex rescues subcellular zinc and calcium mislocalisation in batten disease
      Prof. Anthony White (University of Melbourne)
      20/11/2014, 14:20
      Biological Systems
      Oral
      A hallmark of neurodegeneration is a failure of homeostatic mechanisms controlling the concentration and distribution of biometals. A major roadblock to understanding the impact of altered biometal homeostasis in neurodegenerative disease is the lack of specific and sensitive techniques capable of providing quantitative subcellular information on biometals in situ. Advances in X-ray...
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    4. 116. Probing materials at 100 nm resolution by AFM-based near field FTIR
      Dr Mark Tobin (Australian Synchrotron)
      20/11/2014, 14:40
      Biological Systems
      Oral
      Developments to enable infrared microspectroscopy to extend beyond the far field diffraction limit are being undertaken at several accelerator facilities worldwide. These include the CLIO Free Electron Laser (Paris, France), LNLS (Campinas, Brazil), and the ALS infrared beamline (Berkeley, USA). Without such developments, the spatial resolution in the mid-IR is typically 3 to 5 microns. Two...
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