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    User Meeting 2014

    20–21 Nov 2014
    National Centre for Synchrotron Science
    Australia/Melbourne timezone
    Save the date: User Meeting 2015 - 26-27 November

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    Session

    Structural Biology I

    20 Nov 2014, 11:00
    National Centre for Synchrotron Science

    National Centre for Synchrotron Science

    Australian Synchrotron 800 Blackburn Road Clayton VIC 3168

    Conveners

    Structural Biology I

    • Brett Collins (The University of Queensland)

    Presentation materials

    There are no materials yet.

    1. 8. Winning the battle of Signal vs Noise
      Prof. James Holton (UCSF/LBNL)
      20/11/2014, 11:00
      Structural Biology
      Oral
      The success or failure of any structure determination effort is dictated by the signal-to-noise ratio, so a quantitative understanding of both signal and noise is needed to have the best chance of success and to avoid wasted effort on samples that simply aren’t good enough. There are three main hurdles to every structure determination effort: the Phase Problem, the Amplitude Problem, and the...
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    2. 38. Structural Insights into Bak Activation and Oligomerisation
      Mr Jason Brouwer (Walter and Eliza Hall Institute of Medical Research)
      20/11/2014, 11:30
      Structural Biology
      Oral
      Apoptotic stimuli activate and oligomerise the pro-apoptotic proteins Bak and Bax resulting in mitochondrial outer membrane permeabilisation and subsequent cell death. Crystal structures by Czabotar et al. (2013) provided novel insights into BH3-only induced Bax activation and oligomerisation, namely the separation of the core and latch domains, followed by core domain dimerisation. Here we...
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    3. 40. Human leukocyte antigen-associated drug hypersensitivity.
      Dr Julian Vivian (Monash University)
      20/11/2014, 11:50
      Structural Biology
      Oral
      Abacavir hypersensitivity syndrome (AHS) is a T-cell mediated drug hypersensitivity triggered by the antiretroviral drug abacavir, used in the treatment of HIV infection. It is one of an increasing number of adverse drug reactions found to be associated with specific Human Leukocyte Antigen (HLA) alleles. Occuring exclusively in individuals possessing HLA-B*57:01, this is one of the strongest...
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    4. 82. Structure and function studies on human plasminogen glycoforms
      Dr Ruby Law (Monash University)
      20/11/2014, 12:10
      Structural Biology
      Oral
      Plasminogen is a 7-domain protein (with an N-terminal Pan-apple domain, five kringle domains and a C-terminal serine protease domain) that adopts a closed, activation-resistant conformation in the circulatory system. The recruitment of plasminogen to its target sites is dependant on the lysine binding sites of the kringle domains. Binding to lysine residues on cell receptors and fibrin clots...
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