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    User Meeting 2014

    20–21 Nov 2014
    National Centre for Synchrotron Science
    Australia/Melbourne timezone
    Save the date: User Meeting 2015 - 26-27 November

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    Session

    Radiotherapy and Radiobiology

    21 Nov 2014, 13:45
    National Centre for Synchrotron Science

    National Centre for Synchrotron Science

    Australian Synchrotron 800 Blackburn Road Clayton VIC 3168

    Conveners

    Radiotherapy and Radiobiology

    • Jeff Crosbie (University of Melbourne)

    Presentation materials

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    1. 44. A high resolution in-beam monitor for microbeam radiotherapy
      Dr Christopher Poole (University of Melbourne)
      21/11/2014, 13:45
      Radiotherapy and Radiobiology
      Oral
      Due to the very high dose rates (kGy/s) used in microbeam radiotherapy (MRT), rigorous fluence monitoring is necessary both for pre-treatment verification, and during therapy. We propose an in-beam monitoring system comprised of a 50 μm film of polyethylene terephthalate (PET) metalised with Aluminium positioned in the beam, coupled with a CMOS imaging system for the collection of fluorescence...
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    2. 42. Synchrotron broad beam and MRT radiation induces DNA damage in normal mouse tissues distant from the irradiated volume
      Mrs Jessica Ventura (Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia)
      21/11/2014, 14:15
      Radiotherapy and Radiobiology
      Oral
      Microbeam radiation therapy (MRT) is a novel, preclinical modality, with a unique ability to generate less radiation damage to neighbouring normal tissues, while providing efficient ablation to the tumour mass; compared to the currently used Broad Beam (BB) modality. A comprehensive investigation on the mechanisms and side effects of these modalities have not currently been established. Here...
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    3. 59. High Resolution Imaging of IMBL microbeams.
      Mr Frank Gagliardi (WBRC - Alfred Hospital, RMIT University)
      21/11/2014, 14:35
      Radiotherapy and Radiobiology
      Oral
      High resolution 3D imaging of microbeam radiation therapy (MRT) microbeams produced on the Australian Synchrotron's IMBL has been achieved using laser fluorescent confocal microscopy (LFCM). Radiosensitive dosimeters have been specifically fabricated to suit the extremely high dose of the MRT microbeams and the geometrical needs of the LFCM. Cross-fire, stereotactic and interlaced MRT beams...
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    4. 91. Identification of Genes and Molecular Pathways Regulated by Synchrotron Microbeam Radiotherapy
      Dr Yuqing Yang (University of Melbourne)
      21/11/2014, 14:55
      Radiotherapy and Radiobiology
      Oral
      Synchrotron-generated microbeams radiotherapy (MRT) is a novel preclinical radiotherapy,in which synchrotron-generated X-rays are segmented by a collimator, producing intense microbeams. MRT has been shown to be extremely well tolerated by normal tissues including the central nervous system in animal models when compared to conventional radiotherapy (CRT). The aim of this study was to identify...
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