Structural Biology

Stream Leaders: Marc Kvansakul & Ray Norton

Invited Speakers

Jia-Wei Wu – School of Life Sciences, Tsinghua University, China. Structural and biochemical studies of lipid transfer protein ORPs.

Jia-Wei received her PhD in molecular biology from Institute of Biophysics, CAS in 1999 and conducted her postdoctoral research at Princeton University. She joined Tsinghua University as Professor in structural biochemistry in 2003. Her research interests include studying structure and function of key molecules in metabolism and regulatory mechanisms of kinases and phosphatases in signaling.

Quan Hao – University of Hong Kong. Structural studies of new post-translational modification erasers/readers.

Professor Quan Hao joined the HKU of Medicine as Professor in Physiology and Structural Biology in July 2008. He obtained a BSc degree in Physics from the University of Science and Technology of China (USTC) and PhD in Crystallography from the Chinese Academy of Sciences. He conducted his postdoctoral research at the University of York and the University of Liverpool. He joined De Montfort University (UK) as Lecturer in Biophysics in 1994. Prior to joining HKU, he served as the Director of Macromolecular Facility of Cornell High Energy Synchrotron Source (MacCHESS) and Adjunct Associate Professor of Applied Engineering Physics at Cornell University, USA. His research interests include structural and functional studies of sirtuin family proteins and crystallographic methods.

Hanna Yuan – Institute of Molecular Biology, Academia Sinica, Taiwan. Structural insights into mitochondrial DNA maintenance by nucleases.

Dr. Hanna S. Yuan is the Distinguished Research Fellow in the Institute of Biology, Academia Sinica and the Adjunct Professor in the Institute of Biochemistry and Molecular Biology, National Taiwan University. Dr. Yuan’s lab investigates RNA- and DNA-binding proteins that play key roles in nucleic acids metabolism using the main tool of X-ray crystallography, together with biochemical and biophysical approaches. The overall goal is to discover the structure-based mechanisms of these proteins in RNA/DNA recognition, processing and degradation. Dr. Yuan also serves in the Editorial Board of Journal of Biological Chemistry and the Editorial Advisory Board of Protein Science.

Ichio Shimada – University of Tokyo (Structural Biology) Ichio Shimada is the Professor of Structural Biology in the Graduate School of Pharmaceutical Sciences at the University of Tokyo. His research interests are the development of NMR methodologies for studying larger protein complexes and functional analyses of proteins, including membrane proteins. He has served as Director and Scientific Advisor of the Biomedicinal Information Research Center at the National Institute of Advanced Industrial Science and Technology as well as Dean of the Graduate School of Pharmaceutical Sciences. He is currently a council member of The International Council on Magnetic Resonance in Biological Systems (ICMRBS) and The International Society of Magnetic Resonance (ISMAR) and he was elected an ISMAR fellow in 2017, for his contributions to the field of magnetic resonance.

Michelle Dunstone – Department of Biochemistry & Molecular Biology, Monash University. Title TBC.

A/Prof Michelle Dunstone is an ARC Future Fellow at Monash University. Michelle's lies in discovering the conformational change that occurs in the Membrane Attack Complex / Perforin-like superfamily of pore forming proteins. In 2007 her bioinformatic and crystallography research culminated in the first representative structure of a MAC/perforin-like pore forming proteins. Her research on the fungal toxin, pleurotolysin, explores how these hole-punching proteins work by combining single particle cryo-electron microscopy, biophysics and computational biology. Her most recent research on the Membrane Attack Complex structure not only shows how the immune system uses hole punching proteins to kill bacteria but gives insight in to how these proteins evolve different assembly pathways for different functions.

Brett Collins – Division of Cell Biology and Molecular Medicine, Institute for Molecular Bioscience, The University of Queensland, Brisbane. Title TBC.

Assoc. Prof. Brett Collins's lab is interested in understanding how molecular interactions between proteins and lipids control intracellular membrane trafficking. Current interests include (i) endosomal trafficking by the retromer complex and the sorting nexin protein family, (ii) the formation of plasma membrane structures called caveolae, and (ii) the mechanisms of synaptic vesicle fusion controlled by SNARE proteins. Career highlights include determining the structure of the heterotetrameric AP2 complex that regulates receptor endocytosis at the plasma membrane (Cell, 2002, 2010), providing key insights into the retromer transport assembly (Nat. Struct. Mol. Biol, 2005; Traffic, 2008, Traffic, 2011, Nat. Struct. Mol. Biol., 2016, eLife, 2017), defining a novel family of proteins that regulate endosomal sorting of numerous critical transmembrane cargos (PNAS, 2011, PNAS 2013, PNAS, 2014), and providing the first molecular insights into the assembly of caveolar membrane coat structures (Dev. Cell 2014).


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