Dr
Eva Pereiro
(ALBA synchrotron light source)
24/11/2016, 09:20
In Structural Cell Biology detailed structural and functional descriptions of the different cellular components must be correlated with a topological map of these components at the whole cellular level. Cryo soft X-ray nanotomography (cryo-SXT) is a new complementary approach in this field that can provide information at 50 nm (full-pitch) 3D resolution of the organelle organization in whole,...
Rosalie Hocking
(James Cook University)
24/11/2016, 10:30
One of the greatest challenges of the 21st century will be securing cheap and renewable sources of energy. One of the most promising approaches to this challenge is to design catalysts from earth abundant materials capable of implementing key chemical reactions including the splitting water into hydrogen and oxygen (H2O → H2 + ½O2); the oxidation of hydrogen (H2→ 2H+) and reduction (2H+→ H2)...
Dr
Alistair Evans
(Monash University)
24/11/2016, 10:30
The shape and structure of animals is fundamental to their survival, including how they move and feed: bone shape determines how forces are transmitted from muscles during running and flying, and the microstructure of a tooth dictates whether it will break when crushing food. Our ability to adequately capture the fine-scale 3D structure of biological materials has until recently been very...
Susan Cumberland
(Australian Synchrotron)
24/11/2016, 10:30
The relationship between uranium (U) and organic matter (OM) has received increasing attention in the fields of mining and remediation. Sediments and wetlands with high (%) OM content can accumulate U from groundwater, and over geological timescales lead to ore formations. The Mulga Rock deposit (13K tonnes of U) near Kalgoorlie, WA is one example in Australia, with many other examples found...
Dr
Antony van der Ent
(The University of Queensland, Australia)
24/11/2016, 11:00
Our team, together with international collaborators, has been studying plants that hyperaccumulator trace elements, especially nickel, from various ecosystems around the world. The aim of these investigations has been to advance our understanding of the ecophysiology of these unusual plants.
We have employed a range of micro-analytical methods to reveal the in situ distribution,...
Dr
Tamar Greaves
(RMIT University)
24/11/2016, 11:15
Biological applications which utilise enzymes, or other proteins, require the tertiary structure of the protein to be retained. However, many proteins readily undergo aggregation or denaturation when outside their native environment, and/or over longer timescales. The stability of proteins in solvents other than water is usually considered unappealing due to an assumption that the protein will...
Mr
Andrew Chan
(The University of Auckland)
24/11/2016, 11:15
Transition metal modified titania (M/TiO2, M = Pd, Pt or Au) photocatalysts have shown excellent activity for H2 production in alcohol-water mixtures under UV excitation [1, 2]. Recently, we have found that a 0.25 wt.% Pd-0.25 wt.% Au/TiO2 photocatalyst demonstrated a superior H2 production rate of 68 mmol g-1 h-1 compared to monometallic 0.50 wt.% Pd/TiO2 (43.0 mmol g-1 h-1) or 1.00 wt.%...
Ms
Rebecca Auchettl
(La Trobe University)
24/11/2016, 11:30
Titan is Saturn’s largest moon and is the only planetary body in our solar system with a dense atmosphere that is comparable to Earth. Photochemical processing of the two major atmospheric components (N2 and CH4) produce a suite of hydrocarbon and nitrile species, from small hydrocarbons to large complex organic molecules (COMs) and polymeric nitriles (tholins). Tholins aggregate and coagulate...
Dr
Zhaoming Zhang
(ANSTO)
24/11/2016, 11:30
We have studied the long-range average and short-range local structures in Y2Ti2-xHfxO7 (x = 0-2.0) using diffraction and spectroscopy techniques respectively. Both neutron and synchrotron X-ray powder diffraction data show a clear phase transition of the average structure from ordered pyrochlore to disordered defect-fluorite at x ~ 1.6; the long-range anion disorder appears to develop...
Dr
Christopher Garvey
(ANSTO)
24/11/2016, 11:30
Èlastin is a highly elastic protein found in connective tissue of vertebrates. It has an important mechanical physiological function by virtue of its highly elastic nature, namely to provide recoil in tissue such as skin and vasculature. The structure is extremely stable being produced mainly early in life where it persists and is not replaced during a lifetime. The structure and mechanical...
Dr
Suzanne Neville
(The University of Sydney)
24/11/2016, 11:45
Spin Crossover (SCO) is a phenomenon where a 3d4-7 metal ion reversibly switches between two electronic states, namely high spin (HS) and low spin (LS), under an external perturbation, such as temperature, pressure or light irradiation.[1] SCO behaviour is driven by short- and long-range lattice interactions which enables spin state cooperative propagation throughout the material, resulting in...
Ms
Jing Song
(Sun Yat-sen University; CSIRO Manufacture), Mr
Yuqi Ren
(CSIRO)
24/11/2016, 11:45
The Saturated Fine-Grained (SFG) soil, as one type of important materials of dredger mud, is related closely to bearing capacity of foundation in consolidation progress of reclamation engineering. It is necessary to research the quantitative mechanism between micro and macro mechanics by microstructure evolution of SFG soil consolidation. However, it is difficult to obtain the 3D...
Dr
Mark John Hackett
(Curtin Univeristy)
24/11/2016, 11:45
The hippocampus is a key anatomical brain structure required for spatial learning and memory in all mammals. The structure of the hippocampus is highly conserved between mammalian species, which highlights a fundamental importance to higher order brain function. As such, the hippocampus is one of the most studied anatomical structures in the field of neuroscience. However, much remains unknown...
Dr
Bridget Ingham
(Callaghan Innovation)
24/11/2016, 12:00
Most of the dietary calcium in milk is contained within casein micelles as so-called ‘colloidal calcium phosphate’ (CCP) nanoclusters around 2-3 nm in size. Small-angle X-ray and neutron scattering (SAXS and SANS) have been used for several decades to study the internal structure of bovine casein micelles, but there is lingering controversy over the interpretation of the scattering data...
Mr
Henry Kirkwood
(La Trobe University)
24/11/2016, 12:00
X-ray micro-beam Laue diffraction is a powerful tool for mapping the orientation and elastic strain within polycrystalline materials. Interactions between neighbouring grains influence the macroscale characteristics of a material, particularly its deformation behaviour, damage initiation and propagation mechanisms. Here we report on recent experiments using energy scanning diffraction of a...
Mr
Mahmut Ruzi
(Latrobe University)
24/11/2016, 12:00
Formic acid (HCOOH) is the most abundant trace gas organic acid in the atmosphere, resulting from oxidation or photochemical processing of alkanes from biogenic and anthropogenic sources.[1] Formic acid dissolves well in water and thus contributes significantly to rain acidity in remote regions. Due to its good solubility it is believed that formic acid contributes to cloud condensation.[2] It...
Dr
Geoff Waterhouse
(The University of Auckland)
24/11/2016, 12:15
Global energy concerns motivate the development of new and improved technologies for solar energy capture, with semiconductor photocatalysis expected to make an important contribution towards satisfying the energy needs of future societies. This talk will overview some of our recent research aimed at photocatalyst development for H2 production in alcohol-water mixtures, focussing primarily on...
Dr
Malinda Salim
(Monash University)
24/11/2016, 12:15
Milk provides an important source of energy for children, and is one of the staple foods for adults with Western diet. The World Health Organization and the Australian government have recommended exclusive human milk feeding for infants below 6 months, although commercial infant formulas (IF) can be used as human milk substitute in circumstances where human milk is not adequate.[1,2] IF is...
Dr
Guillermo Narsilio
(Australian Research Conuncil Future Fellow, The University of Melbourne), Dr
Mahdi Disfani
(Senior Lecturer in Geotechnical Engineering)
24/11/2016, 12:15
Synchrotron Radiation-based X-ray Micro-Computed Tomography (SR-µCT) is a leading edge technology allowing unprecedented grain-scale observations helping with a better understanding of geomaterial behavior. The higher energy level used in this technique allows rapid scanning of geomaterials under high stress levels to study the progress of crushing and crack propagation. This paper...
Dr
Alastair Stacey
(School of Physics, The University of Melbourne)
24/11/2016, 13:30
Diamonds exhibit remarkable properties at the confluence of biological and quantum sciences. The crystalline carbon lattice of this material acts as both a quantum vacuum, allowing long lived coherent states at room temperature, while also presenting a bio-friendly interface. Point defects in this material are now being used for an ever expanding array of quantum information and sensing...
Prof.
Colin Jackson
(Australian National University)
24/11/2016, 13:30
Enzymes must be ordered to allow the stabilization of transition states by their active sites, yet dynamic enough to adopt alternative conformations suited to other steps in their catalytic cycles. The biophysical principles that determine how specific protein dynamics evolve and how remote mutations affect catalytic activity are poorly understood. Here we examine a 'molecular fossil record'...
Dr
David Turner
(Monash University)
24/11/2016, 14:00
Chiral metal-organic materials, either infinite coordination polymers or discrete cages/capsules, are areas of considerable research interest due to their potential to act as catalysts for enantioselective reactions or agents to separate and purify racemic mixtures.
Towards these ends, we have recently been investigating a series of enantiopure dicarboxylate ligands, built using diimide...
Chris McNeill
(Monash University)
24/11/2016, 14:00
In thin films of semiconductor polymers, the polymer chains often exhibit distinct orientation with respect to the substrate. The planar π-face of the backbone typically orients either in an edge-on or face-on manner. Generally, an edge-on alignment is thought to be favourable for transport in thin film transistors, whereas face-on alignment is considered to improve vertical transport as...
Dr
Kelan Chen
(Walter and Eliza Hall Institute)
24/11/2016, 14:00
Structural Maintenance of Chromosomes flexible Hinge Domain-containing 1 (SMCHD1) is a non-canonical SMC protein that plays critical roles in epigenetic regulation. Recently, heterozygous loss of function mutations in *SMCHD1* were identified in facioscapulohumeral muscular dystrophy (FSHD) patients, leading to failure of epigenetic silencing of the disease-causing gene *DUX4* in muscle cells....
Ms
Hannah Wells
(Massey University)
24/11/2016, 14:15
Collagen is the main structural component of many natural materials including leather and surgical scaffold materials derived from skin, and heart valve leaflets derived from pericardium. Strength is one of the key characteristics required for the application of these materials however the basis for strength in these materials is not fully understood. We have used small angle X-ray scattering...
Dr
Jitraporn (Pimm) Vongsvivut
(Infrared Microspectroscopy (IRM) Beamline, Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia)
24/11/2016, 14:15
Corrosion of metallic surfaces is prevalent and of great concern in a wide range of industries, particularly those in transport, aviation, building and food sectors, reportedly responsible for a direct cost of $276 billion per annum(1). Galvanization has been widely used as a corrosion preventative method by coating the metallic surfaces with zinc that serves as a physical barrier to prevent...
Dr
Jason Price
(Australian Synchrotron)
24/11/2016, 14:30
The macromolecular (MX) beamlines at the Australian synchrotron are mixed use between the structural biology and chemical crystallography (CX) communities. Since commissioning the high throughput MX1 bending magnet and the MX2 microfocus undulator beamlines have proven very successful for both communities.
With the transfer of the Australian Synchrotron under ANSTO as recognition as its...
Mr
Adam Welford
(Monash University)
24/11/2016, 14:30
Organic semiconductors (OSCs) possess many inherent advantages that allow them to be used effectively as organic field effect transistors (OFETs). Solution processablility allows rapid, large area fabrication on low cost flexible substrate that make them ideal for specialized applications such as flexible displays and radio frequency identification (RFID).
Small molecule OSCs provide...
Dr
Courtney Ennis
(La Trobe University)
24/11/2016, 14:30
The second half of 2016 has seen the completion of a bespoke experiment installed at the THz/Far-IR Beamline. Funded by the ARC through CI Ennis' DECRA project, the apparatus has been designed for dual-purpose Matrix-Isolation and Reflection-Absorption Infrared Spectroscopy studies. A chamber sitting within the beamline’s Bruker FTIR sample compartment reaches high-vacuum by differential...
Mr
Masrur Morshed Nahid
(Monash University)
24/11/2016, 14:45
The interaction between a solvent and semiconducting polymer plays a fundamental role in the formation of thin-films that are used to fabricate solution processed organic electronic devices. Depending on this interaction, polymer chains form different aggregates in a solvent that affects film morphology and in turn, charge transport properties. To realise efficient charge transport in an...
Dr
Vi Khanh Truong
(School of Science, Faculty of Science, Engineering and Technology, Swinburne University of Technology)
24/11/2016, 14:45
Fungi possess the ability to colonize a wide array of surfaces, including metallic surfaces; the product of colonization is the proliferation and formation of a fungal biofilm followed by the degradation and alteration of the metallic surface. In particular, microbially-induced corrosion on the surface of metals occurs due to changes in the local acidity, creating galvanic and differential...
Ms
Radhika Mohandass
(RMIT)
24/11/2016, 15:00
Radhika Mohandass1, Dilek Yalcin1, Calum Drummond1 Tamar Greaves1
1. School of Science, College of Science, Engineering and Health, RMIT University, Melbourne, VIC, Australia
Email: s3607967@student.rmit.edu.au
Ionic liquids (ILs) can have a stabilizing or destabilizing effect on proteins, which is strongly dependent on the cation and anion of the IL (1). Consequently ILs have...
Mr
Lewis Chambers
(University of Queensland)
24/11/2016, 15:00
Block copolymers can self-assemble into well-defined, nanoscale morphologies, which are typically isotropic and lack long range order. Chemical or physical templates generated through optical lithography can direct self assembly to create morphologies with enhanced long range order and fashion them into hierarchical patterns. This ability allows the patterns formed to be optimized to be more...
Prof.
Gary Bryant
(Centre for Molecular and Nanoscale Physics, School of Applied Sciences, RMIT University)
24/11/2016, 15:00
Colloidal suspensions of hard spheres are valuable experimental model systems for exploring phase behaviour and dynamics in condensed matter. Such colloids form colloidal crystals at concentrations above the freezing volume fraction of 0.494, allowing the investigation of the kinetics and dynamics of crystallization. As colloidal particles are much bigger than atoms, processes are...
Dr
Jean-François Adam
(Université Grenoble-Alpes & Centre Hospitalier Universitaire Grenoble-Alpes)
25/11/2016, 11:00
Therapeutic applications of synchrotron x-rays are becoming a reality. The first phase I/II clinical study of Synchrotron Stereotactic Radiation Therapy (SSRT), in place at the European Synchrotron Radiation Facility (ESRF) since 2012, consists of a dose escalation protocol to show the feasibility and safety of the technique. 13 patients have been treated using 80 keV high-flux quasi-parallel...
Dr
Robert Acres
(Australian Synchrotron)
25/11/2016, 11:00
One of Australia’s world class research facilities, the Australian Synchrotron, provides cutting edge tools to academic and industry researchers, empowering them to problem solve and innovate in a wide range of sectors.
As well as servicing the traditional academic user base, the Australian Synchrotron has an Industry Engagement team focused on supporting commercial customers to utilise the...
Mr
Lloyd Smyth
(University of Melbourne, Epworth HealthCare)
25/11/2016, 11:30
Background: Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating paediatric brainstem tumour with extremely poor prognosis and limited treatment options. Radiotherapy is the mainstay treatment but is limited to palliative use. Microbeam Radiotherapy (MRT) is a promising pre-clinical synchrotron radiotherapy modality which could improve the therapeutic ratio between normal tissue toxicity...
Prof.
Bronwyn Fox
(Swinburne University of Technology)
25/11/2016, 11:30
Swinburne’s Factory of the Future is located in the recently opened $100 million Advanced Manufacturing and Design Centre at the university’s main campus in Melbourne, Australia. The Factory of the Future is one of three pillars of Swinburne’s newly launched Innovation Precinct which emphasises design and digital technologies to tackle manufacturing challenges, and pilot production and...
Prof.
Zhonghua Sun
(Curtin University)
25/11/2016, 11:30
This study was conducted on a human aorta phantom with a commercially available stent graft placed in the aorta with the aim of investigating visualization of aortic stent graft by synchrotron radiation. Synchrotron tomography experiments were performed on imaging and medical beamline at the Australian Synchrotron facility, with beam energy ranging from 40 to 100 keV, with spatial resolution...
Francesca Di Lillo
(Dept. of Phys. "Ettore Pancini", University of Naples Federico II,Naples, Italy & INFN, Sez. Napoli, Italy)
25/11/2016, 11:45
In 2012, J. Boone proposed the external-beam kilovoltage radiotherapy of the breast cancer with a dedicated setup adopting an orthovoltage X-ray tube [1] rotating in full circles around the breast, with the woman in prone position. For comparison, conventional radiotherapy for breast cancer adopts a medical linac irradiating the breast with tangential beams, in supine position: the megavoltage...
Dr
Erin McGillick
(The Ritchie Centre, Hudson Institute for Medical Research, Melbourne, Australia & The Department of Obstetrics and Gynecology, Monash University, Melbourne, Australia)
25/11/2016, 11:45
Before birth the fetal lungs are filled with liquid, which must be cleared at birth to allow entry of air and onset of gas exchange. The rate of preterm birth and non-labour caesarean delivery has substantially increased, which delays lung liquid clearance and increases the risk of neonatal respiratory complications. Retention of liquid in airways and/or lung tissue is thought to underpin the...
Prof.
Andrea Gerson
(Blue Minerals Consultancy)
25/11/2016, 11:45
This presentation will provide an overview of industrial studies using synchrotron-based techniques undertaken over the past 20+ years by the presenter. The objective is to provide perspective on the wide scope of possible applications and motivations for industry participation. These applications focus mainly on minerals and materials studies and have included:
• wax crystallisation from...
Dr
Peter Kopittke
(The University of Queensland)
25/11/2016, 12:00
Acid soils comprise ca. 4 billion ha of the global ice-free land or ca. 40 % of the world’s arable land. In these acid soils, the elevated solubility of Al-containing minerals results in increased concentrations of Al in the soil solution. Soluble Al is highly toxic to root growth, reducing elongation of roots in as little as 5 min due to an inhibition of wall loosening as required for cell...
Mrs
Jessica Ventura
(The Department of Obstetrics and Gynaecology, The Royal Women’s Hospital, Melbourne, VIC; Molecular Radiation Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC)
25/11/2016, 12:00
Discovery of the radiation-induced bystander effect (RIBE) demonstrates that cell death and genomic instability are not restricted to cells that are directly exposed to ionising radiation. The RIBE refers to a situation where cells that have not been directly exposed to IR behave as though they have been exposed. This phenomenon presents real clinical consequences such as increased risk of...
Dr
Anton Maksimenko
(Australian Synchrotron)
25/11/2016, 12:15
The Imaging and Medical Beamline (IMBL) of the Australian Synchrotron is recognised as one of the most advanced facility for the Computed Tomography (CT) experiment. It was designed for the macro-imaging, just touching the microscopy ranges in the highest magnification configuration. This design assumes that the beamline must be capable of imaging large objects up to 50cm wide. The...
Prof.
Michael Lerch
(University of Wollongong)
25/11/2016, 12:15
Microbeam radiation therapy (MRT) implements spatially-fractionated kilovoltage x-rays for deep-seated tumour treatment [1,2] to provide better normal tissue sparing [3]. However, tumour treatment with MRT can be further optimized with high-Z nanoparticles (NPs), which have been shown to enhance the dose delivered by conventional radiotherapies [4]. Tantalum pentoxide (Ta2O5) NPs are novel...
Prof.
Peter Rogers
(University of melbourne)
25/11/2016, 13:30
Microbeam radiotherapy (MRT) was proposed as a novel RT paradigm for treating cancer some time ago. However, progress has been slow and it is unclear when or if human cancers will be treated with synchrotron radiation. There are numerous biological, medical, technical, regulatory and ethical issues to consider before a human is subjected to synchrotron MRT.
This talk will give an overview of...
Prof.
Andrea Gerson
(Blue Minerals Consultancy)
25/11/2016, 13:30
Crystalline phase determination, polycrystallinity, strain, grain orientation as well as defect structure, migration and organisation are fundamental to the understanding of materials’ properties. The MMC beamline is the only facility planned for the Australian Synchrotron that will enable these properties to be spatially resolved at the micron scale.
We present the current design and...
Prof.
Emily Parker
(University of Canterbury)
25/11/2016, 13:30
We have used protein crystallography and small angle X-ray scattering to understand the way that enzymes respond to remote signals – a process known as allostery (from the Greek *allos* meaning “other” and *stereos* meaning “solid”). Allostery is critical to the control of metabolism, and although allostery has been known for many years, it is only more recently that the molecular networks...
Dr
Jeremy Wykes
(Macquarie University)
25/11/2016, 14:00
The Macquarie University-Australian Synchrotron D-DIA apparatus is a large-volume solid-media apparatus for high pressure, high temperature in-situ x-ray experiments. The apparatus can subject a sample volume of up to 5 mm^3 to pressures to 6 GPa and temperatures to 1500 °C.
During 2016/2 initial experiments were conducted on the XAS beamline. Uranium and Thorium L3-edge transmission XANES...
Dr
Jason Paxman
(La Trobe University)
25/11/2016, 14:00
Autotransporter proteins are the largest group of outer membrane and secreted virulence factors from important bacterial pathogens such as Salmonella enterica, Shigella flexneri, Neisseria meningitidis and pathogenic E. coli strains. They are important contributors to bacterial pathogenesis, functioning as toxins, adhesins and facilitators of biofilm formation. Their importance to human...
Dr
Nigel Kirby
(Australian Synchrotron), Dr
Tim Ryan
(Australian Synchrotron)
25/11/2016, 14:15
Small angle X-ray scattering (SAXS) is an extremely useful tool for analysing protein structures that is becoming increasingly popular. SAXS displays a number of advantages over other techniques, but radiation damage and sample consumption limit the utility of the technique to the wider protein community. Of the various avenues being pursued to circumvent radiation damage, we have focused...
Mr
Frank Gagliardi
(William Buckland Radiotherapy Centre)
25/11/2016, 14:15
Dosimetric properties of synchrotron microbeams are extremely difficult to measure due to the small field sizes employed (typically 50 um width with 200 – 400 um peak-to-peak spacing) and must undergo rigorous validation before patient treatments can be performed on the IMBL.
The radiochromic PRESAGE® dosimeter offers a unique opportunity to validate dosimetry models in 3D with similar...
Dr
Daniel Eriksson
(Australian Synchrotron)
25/11/2016, 14:15
The micro-crystallography beamline, MX2, depends on three mirror elements for conditioning and focussing the beam at the sample position. One of these, the Microfocussing Horizontally Focussing Mirror (MHFM) is showing signs of beam damage. A likely source of this damage is the high-voltage piezo bender bimorph system used to shape the mirror.
This manifests as significant structure in the...
Dr
Duncan Butler
(ARPANSA)
25/11/2016, 14:30
Detectors using diamond for the active layer are becoming more popular in radiotherapy because they have a relatively flat energy response and can be small. Recently published modelling of a new solid-state diamond detector (PTW model 60019) suggests that only a region of diameter 0.6 mm responds to radiation. The manufacturer’s specifications indicate that the active area is a disk of...
Dr
Jakub Gruszczyk
(The Walter and Eliza Hall Institute)
25/11/2016, 14:30
Understanding the process of invasion is essential for developing strategies to stop blood stage infection. An important feature of *Plasmodium* invasion is the host cell selectivity that the different species have for cells of the erythroid lineage. Indeed, *Plasmodium vivax* preferentially invades reticulocytes which are immature red blood cells. Several members of *P. vivax* Reticulocyte...
Dr
David Aragao
(Australian Synchrotron)
25/11/2016, 14:30
Sample positioning and rotation on the X-ray beam are critical experimental parameters for a successfully experiment . This becomes exacerbated when handling small crystals on a micro-focus beam like the one provided by the MX2 beamline at the Australian Synchrotron. Here it is paramount that the centre of rotation is on the same location as the X-ray beam. For one hand, any procession,...
Prof.
Alice Vrielink
(University of Western Australia)
25/11/2016, 14:45
Multiple drug resistance (MDR) in Gram-negative bacteria represents one of the most intractable problems facing modern medicine. Colistin and polymyxin are cationic antimicrobial peptide antibiotics which permeabilise the bacterial outer membrane and have been used to treat infections. Resistance to these antibiotics is conferred by the modification of the lipid A headgroups with...
Ms
Josie Nunn
(Flinders University SA)
25/11/2016, 14:45
This presentation gives an overview of the development and comparison of different sample preparation techniques for presenting samples to the Far-IR and IR beam line at the Australian Synchrotron.
We have investigated using polyethylene (PE), polytetrafluoroethylene (PTFE), polyvinylacetate (PVA), paraffin, and mixtures, as matrixes for pellets.
We have also trialled pressing pure...
Dr
Jayde Livingstone
(Australian Synchrotron)
25/11/2016, 14:45
There are currently two biomedical synchrotron beamlines in the world with an MRT program and an active MRT user base: ID17 at the European Synchrotron Radiation Facility (ESRF), France, and the Australian Synchrotron’s Imaging and Medical Beamline (IMBL). The European program has been ongoing since the 1990s and has identified radioresistant brain tumours as a clinical target for MRT. Indeed,...
Tom Caradoc-Davies
(Australian Synchrotron.)
25/11/2016, 15:00
The advent of the Eiger family of detectors has pushed the speed of MX experiments to new heights with SAD phasing datasets being collected in as little as 1 second. The Eiger16M can produce 10Tb of data per day at a bandwidth of 40Gb/s. These high data rates come with a range of benefits and challenges for synchrotron facilities. With an Eiger 16M detector scheduled for delivery in December...
David Paterson
(Australian Synchrotron)
25/11/2016, 15:00
Richly detailed high definition elemental images are routinely collected during experiments at the X-ray Fluorescence Microscopy (XFM) beamline [1]. In addition, complex 3D data sets may be collected - X-ray fluorescence tomography and/or XANES image stacks. For many experiments there can be up to ¼ TB of raw data to process from a 3 to 4 day visit.
This presentation will describe the...
Mr
Liam Day
(Royal Melbourne Institute of Technology)
25/11/2016, 15:00
**Introduction**
Synchrotron microbeam radiation therapy (MRT) is a novel radiotherapy modality with significant clinical potential. We have produced a simple dose calculation algorithm for MRT using the Eclipse Treatment Planning System (TPS), by Varian Medical Systems.
**Method**
The calculation engine in Eclipse was configured to directly evaluate ‘peak’ doses. Monte...
Prof.
Bostjan Kobe
(University of Queensland)
25/11/2016, 15:15
TIR (Toll/interleukin-1 receptor, resistance protein) domains are key components of innate immunity signaling pathways. They are found in animals, plants and bacteria, for example in TLRs (Toll-like receptors) and TLR adaptors in animals, NLRs (nucleotide binding, leucine-rich repeat receptors) in plants, and virulence factors interfering with immune responses in bacteria. While it has been...
Prof.
Peter Rogers
(University of melbourne)
25/11/2016, 16:30
Dr
Jean-François Adam
(Université Grenoble-Alpes & Centre Hospitalier Universitaire Grenoble-Alpes)
25/11/2016, 16:45
Stewart Ryan
(University of Melbourne)
25/11/2016, 17:00
Labuc Rob
(Melbourne Veterinary Specialist Centre)
25/11/2016, 17:15
Wheeler Greg
(Peter Mac)
25/11/2016, 17:30
Senthi Sashendra
(The Alfred Hospital)
25/11/2016, 17:45
Mrs
Sirisha Tadimalla
(Queensland University of Technology)
Imaging
Poster
**Background:** Diffusion Tensor Imaging (DTI) is a popular technique used to study collagen fibre architecture in articular cartilage. Interpretation of DTI images, however, is limited to the predominant alignment of fibres only[1]. Dispersion of fibre orientations can be measured using Small angle X-ray scattering (SAXS). Here, we present a comparison of SAXS and DTI measurements in...
Mr
Matthew Cameron
(University of Wollongong)
Radiotherapy
Poster
Microbeam Radiation Therapy (MRT) is a promising preclinical radiotherapy modality that uses micron-sized, spatially fractionated radiation fields to treat radioresistant and otherwise untreatable tumours. A typical MRT configuration consists of arrays of 25-75 µm wide high-dose 'peaks' separated by 100-400 µm wide low-dose 'valleys' that are produced by an x-ray spectrum from a synchrotron...
Ms
Susyn Kelly
(Massey University)
Advanced Materials
Poster
Ovine leather has around half the strength of bovine leather and is therefore not suitable for high value applications such as shoes. For leather from a variety of animals it has been found that the extent of collagen fibril alignment (orientation index) is closely correlated with the strength of the leather. We tested whether biaxial stretching for the duration of tanning or compressing...
Dr
Lars Thomsen
(Australian Synchrotron)
Technique Development
Poster
The Soft X-Ray beamline is in the process of developing a High Vacuum Automated NEXAFS chamber. To this end we have started developing automated methods for collecting NXAFS data on our existing end station. This presentation will describe the latest automated procedures that we have implemented and tested as well as what is yet to come. It is envisioned that many of the automated procedures...
Ms
Jenine McCutcheon
(The University of Queensland)
Earth and Environment
Poster
Beachrock is produced through the lithification of sediments in the intertidal zone of tropical beaches on both continental coastlines and sand cays in reef environments. Beachrock formation through carbonate cement precipitation has the capacity to slow sea-level rise induced erosion of sand cays, islands that host vulnerable habitats, including inhabited cays and sea turtle rookeries....
Ms
Anita Pax
(The ARC Dairy Innovation Hub, The Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria)
Biological Systems
Poster
Fourier transform infrared (FTIR) spectroscopy is a well-established technique for the analysis of dairy products due to its ability to rapidly provide molecular information related to chemical composition. Despite the widespread use of FTIR spectroscopy, FTIR microspectroscopy has only had limited applications in dairy products to date. Current methods of analysis of the microstructure of...
Dr
Dominique Appadoo
(Australian Synchrotron)
Technique Development
Poster
An increasingly wide variety of condensed phase studies have been successfully undertaken at the THz/Far-IR beamline over the past few years. The combination of a small, collimated, and bright synchrotron THz photons with traditional spectroscopic techniques can offer new opportunities to scientists from fields such as nanotechnology, geology, renewable energy sources, forensics, biology,...
Ms
Stephanie Boer
(Monash University)
Advanced Materials
Poster
A series of chiral coordination cage complexes has been synthesised using amino acid substituted diimide ligands. Using a biphenylsulfonediimide core (BPSD) substituted with amino acids, a series of quadruple stranded Cu4L4 cages have been formed. The cages contain two copper paddlewheel units connected by four ligands. Analogous chiral complexes (helicates) and achiral complexes (mesocates)...
Mr
Adrian Emerson
(Monash University)
Advanced Materials
Poster
By directly incorporating amine functionality into the ligand, the adsorption of CO2 into porous coordination polymers has been shown to be increased in comparison to the unfunctionalised frameworks. Using small polyamines such as diethylenetriamine and 1,4-bis(aminomethyl)benzene to synthesise the ligands N,Nʺ-(4-carboxybenzyl)-N,N′,Nʺ-(carboxymethyl)-diethylenetriamine (H5L1) and...
Dr
Chris Garvey
(ANSTO)
Advanced Materials
Poster
Diffraction is a standard technique to study crystal structure, alignment, texture and grain structure in hard matter. The important role of neutron diffraction in (hard) materials has been cemented by the penetrative and non-ionising nature of neutrons allowing non-destructive measurements in quite unusual sample environments, the sensitivity of neutrons to thermal motions, and the...
Mr
chao wang
(monash university)
Advanced Materials
Poster
The photovoltaic properties of a series of diketopyrrolo[3,4-c]pyrrole (DPP) copolymers containing
3,4-ethylenedioxythiophene (EDOT) as a comonomer are reported. With use of different aryl
flanking units on the DPP core, namely thiophene, pyridine or phenyl, optical gaps ranging from
1.91 eV to 1.13 eV are achieved. When blended with the fullerene derivative [6,6]-phenyl C71-
butyric acid...
Dr
Benedicta Arhatari
(La Trobe University)
Imaging
Poster
Here we present x-ray imaging experiments based on the use of Ross filter pairs. Although such Ross filter arrangements have been applied in proof-of-principle spectroscopy experiments, to date there have been no reports of this approach used for full-field x-ray imaging. Here we report on the experimental demonstration of Ross filter pairs being used for quasi-monochromatic, full-field...
Ms
Hannah King
(James Cook University)
Advanced Materials
Poster
Metal oxides are amongst the best known and most extensively studied water oxidation catalysts. Many metal oxide materials function best in a proton accepting electrolyte such as a borate or phosphate buffer. The inclusion of these electrolyte anions in the bulk material (in small amounts) is recognized to result in amorphous metal oxides with “molecular-like” structure. The importance of...
Dr
Andrew Stevenson
(Australian Synchrotron/ CSIRO)
Technique Development
Poster
It is shown that an extensive set of absolute ionisation-chamber (IC) measurements with a primary polychromatic synchrotron X-ray beam and various filter combinations/ thicknesses can be used to quite effectively estimate the flux distribution. The basic technique is simple but the “inversion” of the raw data to extract the flux distribution is fundamentally ill-posed. We demonstrate, using...
Dr
Jeremy Wykes
(Macquarie University)
Earth and Environment
Poster
Fe K-edge XANES was conducted on a suite of synthetic basaltic glasses on both the XAS beamline and the XFM beamline using the Maia detector. The results will be compared.
Mr
Kedar Deshmukh
(Monash University)
Advanced Materials
Poster
All-polymer solar cells employ an electron deficient conjugated polymer as an acceptor in lieu of the ubiquitous fullerene acceptor. All-polymer solar cells have seen a steady rise in efficiency over the past few years going from about 2% to 8.3% with the development of new donor and acceptor polymers. All-polymer solar cells have certain advantages over their fullerene counter parts in terms...
Dr
Daryl Howard
(Australian Synchrotron)
Technique Development
Poster
GeoPIXE is the primary X-ray fluorescence analysis software used at the XFM beamline. Several new developments in GeoPIXE will be outlined, such as fitting for multiple sample matrix phases. Information will be given regarding a GeoPIXE workshop planned for 2017. User input for workshop topics is welcomed.
Mr
Jamie Strachan
(RMIT University)
Biological Systems
Poster
Hybrid protein-lipid materials such as cubosomes are a novel way to encapsulate and protect proteins for a range of nanobiotechnological applications. Peptides and proteins used in new and exciting drug applications may degrade when introduced to the human blood stream, or undergo attack by the immune system. Therefor a biologically stable and safe compound such as a lipid based cubosomes are...
Daniel Hausermann
(Australian Synchrotron)
Imaging
Poster
The Imaging and Medical Beamline (IMBL) has extensive facilities for holding, preparing and performing imaging and radiotherapy experiments with animals.
Animal held and/or prepared to date
- Mice, rats, rabbits, sheep and a piglets.
Animal care
- The IMBL team includes a veterinary surgeon and we can provide excellent support to our users with anesthetics, surgery and animal...
Mr
Greg leblanc
(Australian Synchrotron)
Technique Development
Poster
The fast orbit feedback system in development at the Australian Synchrotron aims to improve the stability of the electron beam by reducing the impact of moving insertion devices and targeting orbit perturbations at the mains frequency (50 Hz, 100 Hz and 300 Hz). The feedback system is designed to have a unity gain at a frequency greater than 300 Hz using a PI controller with harmonic...
Dr
Karagiannis Tom
(Epigenomic Medicine, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia, 3004)
Biological Systems
Poster
Aberrant wound healing, as observed in the presence of co-morbidities such as diabetes, represents a major clinical problem. To improve wound care, a better understanding of the cellular and molecular details of healing processes is required. Our aim was to utilize Synchrotron- and focal plane array (PFA)-based Fourier-transform infrared (FTIR) chemical mapping for further characterizing the...
Dr
Qinfen Gu
(Australian Synchrotron)
Advanced Materials
Poster
Combining synchrotron radiation with various sample environment setups, such as capillary flow cell, we are able to understand the mechanism of gas absorption properties from MOFs and zeolites. In-situ powder X-ray diffraction (PXRD) measurements have been conducted to discover a “molecular trapdoor” mechanism for exclusive gas discrimination, which is demonstrated as an unusual operating...
Ms
Dilek Yalcin Tuncali
(PhD Student)
Biological Systems
Poster
Dilek Yalcin Tuncalia, Radhika Mohandassa, Calum J Drummonda, Tamar L Greavesa
a School of Science, College of Science, Engineering and Health, RMIT University, GPO Box 2476, Melbourne, Victoria 3001, Australia
Protic ionic liquids (PILs) are increasingly being used as solvents for biological molecules due to their desirable properties. Biomolecules such as amino acids, peptides and...
Tessa Charles
(Australian Synchrotron)
Technique Development
Poster
Free Electron Laser (FEL) facilities are capable of producing a peak brightness 10 orders of magnitude above 3rd generation light sources, with 10$^{11}$ to 10$^{13}$ photons per pulse. With ultra-fast pulse durations of 100 fs down to <10 fs, these FELs are capable of imaging structures at the molecular and atomic size level and investigating dynamical processes over timescales that take...
Jun Aishima
(Australian Synchrotron)
Structural Biology
Poster
The ability to determine the progress of an experiment is critical to efficiently use beamtime during synchrotron visits. While processing results from individual datasets are sufficient for many crystallography experiments, chemical crystallography experiments that require use of the minikappa to collect datasets from multiple orientations, and sensitive samples where partial datasets can be...
Bruce Cowie
(Australian Synchrotron.)
Technique Development
Poster
The higher and lower ends of the “Tender” X-ray region are not well defined in photon energy but the core of the range can be considered to be the point at which the two common X-ray monochromator types start to swop over; at present that swop over point is between 1.5 to 2 KeV. The two common monochromators are the double crystal monochromator (DCM) and the grating monochromator. The DCM...
Ms
Kira Rundel
(Monash University)
Advanced Materials
Poster
Organic photovoltaics (OPV) have received much attention due to the promise of low-cost, efficient processing of solar cells onto flexible substrates. Typically, OPVs consist of a polymeric donor and a fullerene acceptor material, however, fullerene shortcomings such as poor light harvesting ability and high synthesis costs have resulted in the exploration of alternative acceptor materials....
Dr
Adrian Hawley
(Australian Synchrotron)
Technique Development
Poster
Observing time resolved changes to weak signals has always been a challenge that the Australian Synchrotron SAXS beamline has been well placed to address. Recent work at the beamline has aimed to find the optimum sample environment and beamline setup for picking out weak signals from in-situ digestion experiments. Aided by some knowledge gained from the i22 beamline at the Diamond synchrotron...
Dr
Chris Hall
(Australian Synchrotron)
Imaging
Poster
IMBL Users have a range of demands for x-ray imaging detectors which cannot be met by one single instrument. For the past four years of operation we have kept a suite of six detectors to match the foreseeable needs. As the beamline has developed in capability over time, the demands on detection have also changed. Furthermore, some of the original detectors are now getting to the end of their...
Mrs
Alaleh Aminzadeh
(Department of Chemistry and Physics, La Trobe Institute of Molecular Science, La Trobe University, Victoria 3086, Australia)
Technique Development
Poster
There is growing interest in combining soft X-ray ptychography with spectroscopy and applying it to the study of functional materials and biological systems in situ [1-3]. Realising the full potential of this method depends on efficient nanofocusing of the X-ray beam. Fresnel zone plates (FZP) are commonly employed, but their efficiency is typically less than 10% [4]. Achieving higher...
Ms
Wan-Ting Chen
(The University of Auckland)
Advanced Materials
Poster
This work targets the development of efficient metal co-catalyst modified titania photocatalysts for alcohol photoreforming to H2 that function under direct sunlight. Conventionally, noble metals such as platinum, palladium or gold have been used co-catalysts to activate TiO2 for hydrogen production, though the use of such co-catalysts for industrial scale H2 manufacture is not feasible due to...
Mr
Nader Afshar
(Controls Engineer)
Imaging
Poster
Data acquisition at virtually every beamline at the AS involves scanning; however, none more so than the XFM beamline, where every pixel in an image is acquired serially by scanning a specimen through a tightly-focused beam. At XFM, faster scanning means more science.
On-the-fly scanning has significantly improved scan speeds by removing overheads between pixels. However, developments in...
Dr
Mark Boland
(University of Melbourne)
Technique Development
Poster
The Australian Synchrotron storage ring has achieved a world record low vertical emittance below 1 pm rad. These beam parameters produce very small beam sizes which are hard to accurately measure. This proposal is to test an Young's Double slit X-ray interferometer on the long baseline of the IMBL to measure vertical electron beam sizes down to 1.6 $\mu$m. These measurements will be part of...
Dr
Simon Royce
(Central Clinical School, Monash University)
Imaging
Poster
Rodent models of allergic airways disease largely replicate the pathophysiology of asthma and are widely used in basic science and in preclinical drug evaluation. The phenotype of allergic airways disease rodents with a genetic deficiency or their response to pharmacological treatment can be assessed according to clinically relevant endpoints including lung function tests. This often takes...
Dr
Simon Royce
(Central Clinical School, Monash University)
Imaging
Poster
Rodent models of allergic airways disease largely replicate the pathophysiology of asthma and are widely used in basic science and in preclinical drug evaluation.The phenotype of allergic airways disease rodents with a genetic deficiency or their response to pharmacological treatment can be assessed according to clinically relevant endpoints including lung function tests.This often takes the...
Dr
Louise Fisher
(CSIRO)
Imaging
Mr
Oliver Heilmann
(Monash University)
Advanced Materials
Poster
Rare earth 4-(4’-methylpenyl)-4-oxo-butanoate, (L) complexes [RE(L)3(H2O)] (RE = Y, La, Ce, Nd, Ho, Er) have been prepared by metathesis reactions between the corresponding rare earth chloride and NaL to assess the potentiality as new corrosion inhibitors. The products were analysed by IR- and NMR-spectroscopy, elemental- and metal analysis and TGA measurements. The single crystal X-ray...
Dr
Jitraporn (Pimm) Vongsvivut
(Infrared Microspectroscopy (IRM) Beamline, Australian Synchrotron, 800 Blackburn Road, Clayton, Victoria 3168, Australia)
Technique Development
Poster
Highly collimated synchrotron-IR beam offers 100-1000 times higher brightness than that of internal IR source used in laboratory-based FTIR instruments, enabling acquisition of high-quality FTIR spectra at diffraction-limited spatial resolution. Such properties make synchrotron-IR an excellent analytical platform for acquiring spatially resolved chemical “mapping” of materials at lateral...
Mr
Owen Beaumont
(Monash University)
Advanced Materials
Poster
Modern hard drive disks (HDDs) store information in the form of magnetic field orientation combinations. Information density / size of HDDS are hence limited by the size of the magnets used to construct the device. Molecules and single ions capable of magnetic hysteresis, termed single molecule magnets (SMMs) and single ion magnets (SIMs), respectively, are of interest then as a means to...
Mr
Blake Mazzitelli
(Monash University)
Structural Biology
Poster
Plasmin is essential for a number of physiological functions including fibrinolysis, tissue
remodelling and wound healing. The conversion of the zymogenic plasminogen to its active,
serine protease form, is an important molecular event that regulates the timely delivery of
active plasmin at the critical locations as required. Furthermore, binding of plasminogen to
cell surface receptors...
Dr
Wasinee Phonsri
(Monash University)
Advanced Materials
Poster
A family of Fe(II) spin crossover complexes with halogen substituted 5-X-N-(8-quinolyl)salicylaldimines (HqsalX, X = F 1, Cl 2, Br 3 and I 4) has been investigated. With N4O2 octahedral environments, a somewhat unusual donor system for Fe(II) spin crossover [1], this is the first time that [Fe(II)(qsal-X)2] complexes have been studied [2]. Compounds 2, 3 and 4 unexpectedly show completed...
Dr
Ming Xie
(Victoria University)
Earth and Environment
Poster
We described a synchrotron Fourier transform infrared (IR) microscope method to characterize fouling layer. Combined fouling with organic foulant and colloidal silica in membrane distillation (MD) was used as an example. The synchrotron IR mapping was capable of revealing the spatial distribution of foulants as well as chemical information of foulant-membrane interface. Our results showed that...
Ms
Susyn Kelly
(Massey University)
Advanced Materials
Poster
The Haverkamp research group at Massey University (NZ), scientists at the Australian Synchrotron, and a number of international companies are collaborating on several research projects into collagen materials using small angle X-ray scattering (SAXS). The research advances basic knowledge by revealing the structural basis of physical properties, boosts understanding which improves industrial...
Ms
ZHIFANG GUO
(Monash university)
Advanced Materials
Poster
Syntheses of high reactivity lanthanoid organometallics (Ln-C), organoamides (Ln-NR2), and aryloxides (Ln-OAr) by redox transmetallation (RT) and redox transmetallation protolysis (RTP) reactions have been widely and successfully studied by using mercury compounds. [1] This report describes a new method to synthesize metal-organic lanthanoid derivatives by using trispentafluorophenylbismuth...
Ms
Nurul F. Ghazali
(School of Chemistry,Monash University)
Advanced Materials
Poster
Lanthanoid-8-quinolinolates and its derivatives have attracted a lot of interest due to their structures and behaviour as single molecular magnets [1-3]. A few multinuclear of lanthanoid complexes with 2-methyl-8-hydroxyquinoline (HMQ) were successfully synthesized at elevated temperature using a Teflon Sealed autoclave. It was observed that heating the mixture above the boiling point of the...
Mr
Lloyd Smyth
(University of Melbourne, Epworth HealthCare)
Radiotherapy
Poster
Background: Synchrotron Radiotherapy is characterised by high intensity beams which are capable of delivering dose-rates that are up to 10,000 times faster than conventional radiotherapy dose rates. Systematic normal tissue toxicity data is required in order to progress towards human clinical trials.
Aim: To assess the safety profile of both Synchrotron broad-beam radiotherapy (SBBR) and...
Catherine Chen
(The University of Sydney)
Biological Systems
Poster
Platinum(II) based anti-cancer drugs are the most successful class of chemotherapy drugs in clinical use and are used to treat half of all patients undergoing chemotherapy. Despite their success they are often associated with dose limited toxicities, severe side effects and drug resistance.[1-3]
Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems...
Ms
Mayada Sabri
(Dr Rosalie Hocking,Hannah King)
Advanced Materials
Poster
Birnessites and closely related phases of manganese oxides are catalysts for a range of chemical reactions. These include the classical chemical demonstration of the disproportionation of hydrogen peroxide, decarboxylation reactions, the oxidation of amines to imines and water oidation. Because these reactions are so different we seldom think about the selectivity of one reaction and what it...
Prof.
Emily Parker
(University of Canterbury)
Structural Biology
Prof.
Colin Jackson
(Australian National University)
Structural Biology
Mr
Oliver Sterritt
(University of Canterbury)
Structural Biology
Poster
*Pseudomonas aeruginosa* is an opportunistic human pathogen associated with the chronic infection of the lungs of Cystic Fibrosis patients – New Zealand’s most common lethal genetic disease. *P. aeruginosa* has an innate resistance to antibiotics and concerns exist around the appearance of multi-drug resistant strains [1].
The shikimate pathway is responsible for the biosynthesis of key...
Mr
Anurag Parihar
(Monash University), Ms
Vibhuti Chhabra
(Monash University)
Earth and Environment
Poster
Low-rank fuels such as biomass and mixed municipal solid waste (MSW) can be valorised into useful products ranging from chemicals to bio-oil through thermochemical treatment. However, disparate physical and chemical properties of these fuels entail usage of different heating rates for isolating the product of interest. Rapid thermal degradation of biomass is conducive for producing chemicals...
Dr
Espen Bojesen
(Monash Centre for Electron Microscopy)
Advanced Materials
Poster
The formation and growth of nanoparticles is of critical importance in a variety of scientific areas and in everyday life. The prevailing models used to describe these processes have mainly been based on thermodynamic arguments and by the use of concepts such as “monomers” or “particles”, thereby omitting to incorporate the important influence of differences in the chemical nature of different...
Dr
Martin de Jonge
(Australian Synchrotron)
Technique Development
Poster
The spatial distribution of metals can provide key information for a range of studies. Metals are key to virtually every aspect of life, including health, culture, society, nutrition, and technology. This poster will outline the fundamental concepts in X-ray Fluorescence Microscopy, providing points of departure for understanding the method and its application. We actively encourage...
